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Fronto-Cerebellar Neurometabolite Alterations After Methylphenidate in Children and Adolescents With Adhd: A Proton Magnetic Resonance Spectroscopy Study Publisher Pubmed



Bakhshi S1, 2 ; Tehranidoost M1, 3 ; Batouli SAH3
Authors
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Authors Affiliations
  1. 1. Institute for Cognitive Science Studies, Tehran, Iran
  2. 2. Shahid Beheshti University, Tehran, Iran
  3. 3. Tehran University of Medical Sciences, Iran

Source: Journal of Attention Disorders Published:2023


Abstract

Objective: The fronto-cerebellar circuit is involved in ADHD pathophysiology. Methylphenidate, as a first-line medication for ADHD, affects different brain regions, however, its effect on the fronto-cerebellar circuit is not investigated sufficiently. We aimed to investigate the effect of 8-week treatment with methylphenidate on neurometabolite ratios in the fronto-cerebellar circuit in ADHD participants using magnetic resonance spectroscopy (MRS). Methods: Fifteen drug-naive ADHD children and adolescents were enrolled in the present study. Two single-voxel MR spectra were acquired from the right dorsolateral prefrontal cortex (DLPFC) and left Crus 1, before and after the medication. Also, neuropsychological and behavioral assessments were administered. Results: After medication, the glutamate/creatine in the DLPFC and the choline/creatine in the Crus 1 decreased in the ADHD participants. Conclusion: These findings propose that methylphenidate-induced metabolite changes in the fronto-cerebellar circuit could be associated with improvement in cognitive/behavioral characteristics in ADHD. Also, results highlighted cerebellar engagement in ADHD pathophysiology. © The Author(s) 2023.
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