The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population

The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population Publisher

Charati H^{1, 2} ; Jabbari Ori R³ ; Aghajanpourmir M^{4, 5} ; Esmailizadeh A³ ; Zhang YP^{1, 2, 6, 7, 8}

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1. State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, 650223, China
2. Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, 650204, China
3. Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, 76169-133, Iran
4. Department of Genetics, Faculty of Medicine, Babol University of Medical Sciences, Babol, 4719173716, Iran
5. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, 14155-6447, Iran
6. KIZ/CUHK Joint Laboratory of Bio-resources and Molecular Research in Common Diseases, Kunming, 650223, China
7. State Key Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming, 650091, China
8. Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, 650223, China

Source: Gene Reports Published:2020

Abstract

Background: A strong association of the –13910 C/T polymorphism with body mass index (BMI) and obesity has been previously reported in Europeans and Chilean goat herders. We aimed to examine the relationship of lactase persistence allele –22018 G/A with BMI and clinical characteristics in an Asian populations. Methods: We collected 400 samples from seven Iranian ethnic groups, from whom we investigated their lactose tolerance and screened the genetic variants in their lactase gene locus. Height, weight and clinical characteristics were directly measured. WHO classification of BMI was used. Results: The results indicated that Increasing BMI increased significantly the risk of blood pressure and fasting glucose and decreased body temperature in the studied population. We showed that the –22018 G/A allele was positively associated with BMI in Iranian and Asian populations (P < 0.05). Conclusion: In conclusion, in Asian population-based 7 major Iranian populations, we found evidence for association of the lactase persistence allele –22018*A with BMI and weight. In the future, meta-analysis of genome-wide association (GWA) studies with larger sample sizes are warranted to confirm our finding. © 2020 Elsevier Inc.

2. Apoa2 −256T>C Polymorphism Interacts With Saturated Fatty Acids Intake to Affect Anthropometric and Hormonal Variables in Type 2 Diabetic Patients, Genes and Nutrition (2015)

3. Body-Mass Index and Diabetes Risk in 57 Low-Income and Middle-Income Countries: A Cross-Sectional Study of Nationally Representative, Individual-Level Data in 685 616 Adults, The Lancet (2021)

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Farshad Farzadfar (1)

Style	Citing Format
MLA	Charati H, et al.. "The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population." Gene Reports, vol. 19, no. , 2020, pp. -.
APA	Charati H, Jabbari Ori R, Aghajanpourmir M, Esmailizadeh A, Zhang YP (2020). The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population. Gene Reports, 19(), -.
Chicago	Charati H, Jabbari Ori R, Aghajanpourmir M, Esmailizadeh A, Zhang YP. "The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population." Gene Reports 19, no. (2020): -.
Harvard	Charati H et al. (2020) 'The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population', Gene Reports, 19(), pp. -.
Vancouver	Charati H, Jabbari Ori R, Aghajanpourmir M, Esmailizadeh A, Zhang YP. The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population. Gene Reports. 2020;19():-.
BibTex	@article{ author = {Charati H and Jabbari Ori R and Aghajanpourmir M and Esmailizadeh A and Zhang YP}, title = {The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population}, journal = {Gene Reports}, volume = {19}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Charati H AU - Jabbari Ori R AU - Aghajanpourmir M AU - Esmailizadeh A AU - Zhang YP TI - The Lactase Persistence Allele –22018 G/A Associated With Body Mass Index in an Asian Population JO - Gene Reports VL - 19 IS - SP - EP - PY - 2020 ER -

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