Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Inverse Association of Peripheral Orexin-A With Insulin Resistance in Type 2 Diabetes Mellitus: A Randomized Clinical Trial Publisher Pubmed



Zarifkar M1 ; Noshad S1 ; Shahriari M1 ; Afarideh M1 ; Khajeh E1 ; Karimi Z1 ; Ghajar A1 ; Esteghamati A1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Review of Diabetic Studies Published:2017


Abstract

AIMS: To investigate the association between serum orexin concentrations and insulin resistance/sensitivity in a sample of patients with type 2 diabetes mellitus, and to study the effects of anti-hyperglycemic treatment on orexin concentrations over three months. METHODS: This study was designed as a randomized, open-label, clinical trial. Before allocation, sixty medication-naive, newly-diagnosed, type 2 diabetes patients underwent a 75 g oral glucose tolerance test (OGTT). Afterwards, using a randomized trial design (IRCT201102275917N1) patients were allocated to either the metformin (1000 mg daily) or pioglitazone (30 mg daily) arm, and were reexamined after three months. Serum insulin, plasma glucose, and orexin concentrations were measured at baseline, during OGTT, and after three months. RESULTS: Orexin concentrations significantly decreased after OGTT (0 vs. 120 min: 0.63 ± 0.07 vs. 0.31 ± 0.03 ng/ml, p <0.001). Insulin resistance determined by homeostasis model assessment of insulin resistance (HOMA-IR) was significantly and negatively correlated with orexin (r = -0.301, p = 0.024). Furthermore, orexin concentrations were significantly and positively correlated with the insulin sensitivity index derived from OGTT (r = 0.326, p = 0.014). Threemonth treatment with metformin and pioglitazone significantly improved insulin sensitivity and increased orexin concentrations by 26% (p = 0.025) and 14% (p = 0.076), respectively. Between-group analysis showed that changes in orexin concentrations with metformin and pioglitazone were not significantly different (p = 0.742). CONCLUSIONS: There was a negative association between peripheral orexin concentrations and insulin resistance in type 2 diabetes patients. Three-month anti-hyperglycemic treatment with proportionate doses of metformin or pioglitazone increased orexin concentrations via amelioration of insulin resistance and improvement of glycemic control. © by Lab & Life Press/SBDR.
Related Docs
1. Untangling Narcolepsy and Diabetes: Pathomechanisms With Eyes on Therapeutic Options, Brain Research (2019)
2. Metabolic Profile in Patients With Narcolepsy: A Systematic Review and Meta-Analysis, Sleep Medicine (2021)
3. The Orexin Receptors in the Ventral Tegmental Area Are Involved in the Development of Sensitization to Expression of Morphine-Induced Preference in Rats, Behavioural Pharmacology (2020)
4. Phospholipase Cβ3 in the Hippocampus May Mediate Impairment of Memory by Long-Term Blockade of Orexin 1 Receptors Assessed by the Morris Water Maze, Life Sciences (2020)
5. Orexin Receptor Antagonists in the Pathophysiology and Treatment of Sleep Disorders and Epilepsy, Neuropeptides (2023)
6. Connecting the Dots: An Updated Review of the Role of Autoimmunity in Narcolepsy and Emerging Immunotherapeutic Approaches, Sleep Medicine (2024)
7. Orexin Type-1 Receptor Inhibition in the Rat Lateral Paragigantocellularis Nucleus Attenuates Development of Morphine Dependence, Neuroscience Letters (2020)
8. Inhibition of Orexin Receptor 1 Contributes to the Development of Morphine Dependence Via Attenuation of Camp Response Element-Binding Protein and Phospholipase Cβ3, Journal of Chemical Neuroanatomy (2020)
Experts (# of related papers)
View all Related Experts
Nima Rezaei (2)
Ahmad Reza Dehpour (1)