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Protective Effects of Synbiotic Soymilk Fortified With Whey Protein Concentrate and Zinc Sulfate Against Bile Duct Ligated-Induced Hepatic Encephalopathy Publisher



Jalilpiran Y1, 2 ; Tanideh N3 ; Rahmdel S4 ; Azarpira N5 ; Mokhtari M6 ; Mazloom Z1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran
  3. 3. Stem Cell and Transgenic Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  4. 4. School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
  5. 5. Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2020


Abstract

Aim: This study aimed to compare the effects of synbiotic soymilk fortified with whey protein concentrate and zinc sulfate with lactulose on bile duct ligated-induced HE. Background: Hepatic encephalopathy (HE) is seriously associated with neuromuscular and cognitive alterations. Methods: Eighty-two Sprague Dawley rats were randomly assigned into seven groups (sham, bile duct ligation (BDL), BDL + lactulose, BDL + soymilk (SM), BDL + Synbiotic soymilk (SSM), BDL + SSM + whey protein concentrate (WPC), BDL + SSM + WPC + ZnSO4). Different SM products, lactulose, and normal saline were administered via oral gavage (2 mL/rat/day). The serum and liver markers as well as liver histopathology were assessed after 28 days. Results: The SM products significantly reduced the serum alanine aminotransferase, albumin, and ammonia (P < 0.05). The levels of aspartate aminotransferase, endotoxin, and liver interleukin-6 improved significantly in all treatments, except for those receiving SM. SSM and SSM + WPC + ZnSO4 were the only effective products in reducing serum alkaline phosphatase (P < 0.05). Furthermore, the liver total antioxidant capacity was greater (P<0.05) in the SSM + WPC and SSM + WPC + ZnSO4 groups. The histopathological examinations confirmed the efficiency of all SM products in reducing liver fibrosis. Liver bile duct proliferation diminished only in the SSM + WPC and SSM + WPC+ ZnSO4 groups (P<0.05). Conclusion: This study showed the positive effects of different SM products, especially SSM + WPC and SSM + WPC + ZnSO4, on HE. Further studies are required to confirm our findings. © 2020 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
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