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Toxicity of Zinc Oxide Nanoparticles on Adult Male Wistar Rats Publisher Pubmed



Abbasalipourkabir R1 ; Moradi H2 ; Zarei S3 ; Asadi S1 ; Salehzadeh A4 ; Ghafourikhosroshahi A5 ; Mortazavi M6 ; Ziamajidi N1
Authors
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Authors Affiliations
  1. 1. Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Clinical Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, School of Medicine, Yazd University of Medical Sciences, Yazd, Iran
  4. 4. Department of Entomology and Toxicology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  5. 5. Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

Source: Food and Chemical Toxicology Published:2015


Abstract

The purpose of this study was to investigate the effects of zinc oxide nanoparticles (nZnO) on adult male Wistar rats. Thirty male Wistar rats divided into five groups of six animals each were used for this study. For ten days, Groups one to four continuously received 50, 100, 150 and 200 mg/kg nZnO, respectively. Group five served as the control group. At the end of the study, the rats were sacrificed and histopathological study of the liver and renal tissue, sperm analysis, serum oxidative stress parameters and some liver enzymes were done. The results of this study showed that nZnO at concentration more than 50 mg/kg lead to significant changes in liver enzymes, oxidative stress, liver and renal tissue and sperm quality and quantity. In conclusion, the toxicity of nZnO is more significant when the concentration is increased; however, the use of low doses requires further investigation. © 2015 Elsevier Ltd.
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