Potential Toxic Effects of Zirconia Oxide Nanoparticles on Liver and Kidney Factors



Arefian Z¹ ; Pishbin F¹ ; Negahdary M² ; Ajdary M³ Show Affiliations
Source: Biomedical Research (India) Published:2015

Abstract

Nanoparticles In addition to the positive aspects of tending to its toxicity in the environment is unavoidable. This research studies the effects of ZrO2 NPs on the liver and kidney tissues as well as the activities in liver and kidney enzymes in the male rats. This study is done on 40 Wistar rat race, in 4 groups which includes on control and 3 experimental groups that are monitored daily, for the control group we give a Saline Solution and 3 other with 1ml/day nanoparticle by different doses (50,25,100 ppm) intra-peritoneally. After a 1 week period, samples were unconscious, blood sample were collected from the heart and the ALT, AST, ALP and creatinine were measured. Post-treatment tissue level of malondialdehyde as well as the activities of catalase, glutathione peroxidase and superoxide dismutase were measured in the liver. The statistical raw data was analyzed by SPSS statistical software. The significant difference (p<0.05) in the levels of foregoing factors was obtained by the application of the maximum density of ZrO2NPs (100ppm) in comparison with the control groups. The rats when exposed to a high dosage of nanoparticles reported a significant increase in MDA concentration level while significant decreases were observed in GPX , CAT and SOD activities (P<0.001). In the rats which were exposed to high dosage of nanoparticles, the liver enzyme concentration was significantly increased (p<0.05). The obtained results revealed the significant role of ZrO2 as an increasing ROS generation agent and the ROS have induced the development of free radicals. © 2015, Scientific Publishers of India. All rights reserved.