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Vitamin D Receptor Gene Polymorphisms and Susceptibility to Type 2 Diabetes: Evidence From a Meta-Regression and Meta-Analysis Based on 47 Studies Publisher



Aravindhan S1 ; Almasoody MFM2 ; Selman NA3 ; Andreevna AN4 ; Ravali S5 ; Mohammadi P6 ; Eslami MM7 ; Razi B7 ; Aslani S8 ; Imani D9
Authors
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Authors Affiliations
  1. 1. Department of Electronics and Communication Engineering, Al-ameen Engineering College (Autonomous), Erode, 638 104, Tamil Nadu, India
  2. 2. College of Medicine, University of Babylon, Hillah, Iraq
  3. 3. College of Medicine, University of Babylon, Babil, Iraq
  4. 4. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
  5. 5. Department of Pharmacy Practice, SRM College of Pharmacy, SRM Institute of Science and Technology, Chennai, India
  6. 6. Department of Clinical Biochemistry, School of Medicine, Tarbiat Modares University, Tehran, Iran
  7. 7. Department of Hematology, School of Medicine, Tarbiat Modares University, Tehran, Iran
  8. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Diabetes and Metabolic Disorders Published:2021


Abstract

Background: Evidence from various studies suggest that vitamin D receptor (VDR) gene polymorphisms are associated with type 2 diabetes (T2D); However, these results have been disputable. Here we conducted a meta-analysis to comprehensively evaluate the effect of VDR gene polymorphisms and susceptibility to T2D. Methods: All relevant studies reporting the association between VDR gene polymorphisms and susceptibility to T2D published up to August 2020 were identified by comprehensive systematic database search in web of science, Scopus, and Medline. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to measure strength of association. The methodological quality of each study was assessed according to the Newcastle–Ottawa Scale. Subgroup and meta-regression analysis were also performed. Results: A total of 47 case–control studies were included in this meta-analysis. The overall population results revealed a significant association between FokI, and BsmI (heterozygote model) polymorphisms and T2D in the overall analysis. However, no association was found with the TaqI and ApaI polymorphisms. Moreover, the pooled results of subgroup analysis by ethnicity suggested significant association between FokI, TaqI, and BsmI polymorphisms and T2D in some subgroups. Meta-regression analyses indicated that none of the publication year, ethnicity, and genotyping method were the source of heterogenicity in all four polymorphisms. Conclusions: This meta-analysis suggested a significant association between VDR gene FokI, and BsmI (heterozygote model) polymorphisms and T2D susceptibility in overall population and ethnic-specific analysis. © 2021, Springer Nature Switzerland AG.
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