Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Ercc2/Xpd Polymorphisms and the Risk of Head and Neck Carcinoma: A Systematic Review, Meta-Analysis, Trial Sequential Analysis, Network Analysis, and Functional Effects Publisher Pubmed



Imani MM1 ; Ashabi A2 ; Rezaei F3 ; Saffar Shahroudi A4 ; Kashkouli S5 ; Sadeghi E6 ; Sadeghi M6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Orthodontics, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran
  3. 3. Department of Oral and Maxillofacial Surgery, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Dental Research Center, Dentistry Research Institute, Department of Orthodontics, Dental School, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Prosthodontics, Dental School, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran

Source: BMC Oral Health Published:2025


Abstract

Objectives and aims: The combination of genetic and environmental factors may contribute to the carcinogenesis of HNC. Despite the reported associations between xeroderma pigmentosum group D (XPD) polymorphisms and HNC, the results have been inconsistent, with different studies reporting varying results. Therefore, our aim is to assess the association of three XPD polymorphisms (rs13181, rs1799793, and rs238406) in a comprehensive meta-analysis. Materials and methods: An exhaustive literature review was performed across several databases, including PubMed, Web of Science, Scopus, and Cochrane Library, up to November 18, 2023, without any restrictions. The effect sizes were presented as the odds ratio (OR) with a 95% confidence interval (CI). Results: Thirty-nine articles including 56 studies were entered into the meta-analysis. Evaluating rs13181, rs1799793, and rs238406 polymorphisms in five genetic models, just significant associations were found for rs1799793 polymorphism in heterozygous and dominant models. The findings reported that the ethnicity and the cancer subtype for rs13181, the ethnicity, the sample size, and the control source for rs1799793, and the ethnicity and the control source for rs238406 polymorphisms were effective factors in the pooled results. Trial sequential analysis suggested that the studies included an insufficient number of individuals. Sensitivity analysis reported stability of pooled results. The XPD protein variants were predicted to be benign. Conclusions: The study reveals a significant association between the rs1799793 polymorphism and HNC, but not rs13181 and rs238406 polymorphisms. Future studies should also aim to minimize the impact of confounding factors and heterogeneity to ensure more accurate results. © The Author(s) 2025.
Related Docs
View other Related Docs
1. Association of N-Acetyltransferases 1 and 2 Polymorphisms With Susceptibility to Head and Neck Cancers—A Meta-Analysis, Meta-Regression, and Trial Sequential Analysis, Medicina (Lithuania) (2021)
2. Impact of Alcohol Dehydrogenase 3 (Adh3 or Adh1c) Genetic Variation on Head and Neck Cancer Susceptibility: A Systematic Review, Meta-Analysis, Functional Analysis, and Trial Sequential Analysis, Pathology Research and Practice (2024)
3. Evaluation of Plasma/Serum Adiponectin (An Anti-Inflammatory Factor) Levels in Adult Patients With Obstructive Sleep Apnea Syndrome: A Systematic Review and Meta-Analysis, Life (2022)
4. A Systematic Review and Meta-Analysis to Evaluate Blood Levels of Interleukin-6 in Lung Cancer Patients, Kardiochirurgia i Torakochirurgia Polska (2023)
5. Association of Blood Mcp-1 Levels With Risk of Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis, Medicina (Lithuania) (2022)
6. Evaluation of Blood Levels of Omentin-1 and Orexin-A in Adults With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis, Life (2023)
7. Evaluation of Blood Intercellular Adhesion Molecule-1 (Icam-1) Level in Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis, Medicina (Lithuania) (2022)
8. Association Between the Cyp1a1 Mspi Polymorphism and Risk of Head and Neck Cancer: A Meta-Analysis, Scientific Reports (2022)
Experts (# of related papers)
View all Related Experts
Ata Garajei (4)
Shahriar Nafissi (2)
Other Related Docs
9. Effect of Continuous Positive Airway Pressure on Changes of Plasma/Serum Ghrelin and Evaluation of These Changes Between Adults With Obstructive Sleep Apnea and Controls: A Meta-Analysis, Life (2023)
10. Evaluation of Serum and Salivary Iron and Ferritin Levels in Children With Dental Caries: A Meta-Analysis and Trial Sequential Analysis, Children (2021)
11. Association Between Il-8 (-251T/A) and Il-6 (-174G/C) Polymorphisms and Oral Cancer Susceptibility: A Systematic Review and Meta-Analysis, Medicina (Lithuania) (2021)
12. Primary and Secondary Microcephaly, Global Developmental Delay, and Seizure in Two Siblings Caused by a Novel Missense Variant in the Znf335 Gene, Journal of Molecular Neuroscience (2022)
13. Detection of Variants in Dystroglycanopathy-Associated Genes Through the Application of Targeted Whole-Exome Sequencing Analysis to a Large Cohort of Patients With Unexplained Limb-Girdle Muscle Weakness, Skeletal Muscle (2018)
14. Advances in Therapeutic Targeting of Immune Checkpoints Receptors Within the Cd96-Tigit Axis: Clinical Implications and Future Perspectives, Expert Review of Clinical Immunology (2022)
15. In Silico Analysis for Determining the Deleterious Nonsynonymous Single Nucleotide Polymorphisms of Brca Genes, Molecular Biology Research Communications (2019)
16. The Safety and Efficacy of Binimetinib for Lung Cancer: A Systematic Review, BMC Pulmonary Medicine (2024)
17. Evaluation of the Expression Levels of Mir-21-5P and Mir-429 Genes in Biopsy Samples From Patients With Oral Squamous Cell Carcinoma, Diagnostics (2023)
18. Vitamin D Receptor Gene Polymorphisms and Susceptibility to Urolithiasis: A Meta-Regression and Meta-Analysis, BMC Nephrology (2020)
19. A Mutational Hotspot in the Lamp2 Gene: Unravelling Intrafamilial Phenotypic Variation and Global Distribution of the C.877C>T Variant: A Descriptive Study, Cell Journal (2024)
20. Association of Il2ra and Multiple Sclerosis Risk: A Case Control, Systematic Review, and Meta-Analysis Study, Journal of the Neurological Sciences (2025)
21. Artificial Intelligence in Breast Cancer Survival Prediction: A Comprehensive Systematic Review and Meta-Analysis, Frontiers in Oncology (2024)
22. Association Between Interleukin-1 Polymorphisms and Susceptibility to Dental Peri-Implant Disease: A Meta-Analysis, Pathogens (2021)
23. Neutrophil to Lymphocyte Ratio and Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis, Journal of Arthroplasty (2024)
24. Association Between Adhering to a Dietary Approach to Stop Hypertension and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis, BMC Gastroenterology (2025)
25. Adult-Onset Very-Long-Chain Acyl-Coa Dehydrogenase Deficiency (Vlcadd), European Journal of Neurology (2020)
26. Polymorphism of the Dna Repair Gene Xdp Increases the Risk of Systemic Lupus Erythematosus But Not Multiple Sclerosis in the Iranian Population, Multiple Sclerosis and Related Disorders (2021)
27. Microrna-184 in the Landscape of Human Malignancies: A Review to Roles and Clinical Significance, Cell Death Discovery (2023)
28. Low Expression of Isocitrate Dehydrogenase 1 (Idh1) R132h Is Associated With Advanced Pathological Features in Laryngeal Squamous Cell Carcinoma, Journal of Cancer Research and Clinical Oncology (2023)