Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Sleep Profiles in Epilepsy Patients Undergoing Monotherapy and Polytherapy: A Comparative Cross-Sectional Study Publisher Pubmed



Arvin A1, 5 ; Taebi M1, 6 ; Khazaeipour Z3 ; Najafi A4 ; Tafakhori A2 ; Ranjibourachaloo S2 ; Amirifard H2
Authors
Show Affiliations
Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences (TUMS), Iran
  2. 2. Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Brain & Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Occupational Sleep Research Center, Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Center for Orthopedic Trans-Disciplinary Applied Research, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Epilepsy and Behavior Published:2024


Abstract

Objective: Sleep disturbances commonly reported among epilepsy patients have a reciprocal relationship with the condition; While epilepsy and anti-seizure medications (ASMs) can disrupt sleep structure, disturbed sleep can also exacerbate the frequency of seizures. This study explored subjective sleep disturbances and compared sleep profiles in patients who underwent ASM monotherapy and polytherapy. Methods: We enrolled 176 epilepsy patients who completed a structured questionnaire containing demographic and clinical information and the Persian versions of the Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), and Patient Health Questionnaire-9 (PHQ-9) to evaluate sleep quality, insomnia, excessive daytime sleepiness (EDS), and depressive symptoms, respectively. Chi-square and Mann-Whitney U tests were employed to analyze the association between variables, and logistic regression analysis was conducted to identify factors predicting sleep disturbances. Results: Comparative analysis of mono/polytherapy groups revealed a significantly higher prevalence of insomnia and EDS among patients on polytherapy compared to monotherapy. However, no significant difference was found in sleep quality between the two groups. Logistic regression analysis revealed that a depressive mood serves as a robust predictor for sleep issues, whereas treatment type did not emerge as an independent predictor of sleep disturbances. Conclusion: Our findings suggest that an increased number of ASMs does not inherently result in a higher incidence of sleep issues. Therefore, multiple ASMs may be prescribed when necessary to achieve improved seizure control. Furthermore, this study underscores the importance of comprehensive management that addresses seizure control and treating affective symptoms in individuals with epilepsy. © 2024 Elsevier Inc.
Related Docs
View other Related Docs
1. Psychometric Properties of the Persian Pittsburgh Sleep Quality Index for Adolescents, International Journal of Environmental Research and Public Health (2020)
2. Mothers and Their Children’S Health (Match): A Study Protocol for a Population‐Based Longitudinal Cohort, BMC Pregnancy and Childbirth (2021)
3. Effects of Treatment of Sleep Disorders on Sleep, Psychological and Cognitive Functioning and Biomarkers in Individuals With Hiv/Aids and Under Methadone Maintenance Therapy, Journal of Psychiatric Research (2020)
4. Visual Attention and Poor Sleep Quality, Frontiers in Neuroscience (2022)
5. Comparison of Prevalence Rates of Restless Legs Syndrome, Self-Assessed Risks of Obstructive Sleep Apnea, and Daytime Sleepiness Among Patients With Multiple Sclerosis (Ms), Clinically Isolated Syndrome (Cis) and Neuromyelitis Optica Spectrum Disorder (Nmosd), Sleep Medicine (2020)
6. Compared to Individuals With Mild to Moderate Obstructive Sleep Apnea (Osa), Individuals With Severe Osa Had Higher Bmi and Respiratory-Disturbance Scores, Life (2021)
7. Sleep Disturbance in Alopecia Areata: A Cross-Sectional Study, Health Science Reports (2022)
8. Sleep Characteristics of Iranian People and Their Effects on Daytime Functioning: A Population-Based Study, Scientific Reports (2022)
Experts (# of related papers)
View all Related Experts
Khosro Sadeghniat (14)
Arezu Najafi (7)
Other Related Docs
9. Validity and Reliability of the Persian Version of the Insomnia Diurnal Impact Scale (Idis), Sleep and Breathing (2021)
10. Cross-Cultural Adaptation and Psychometric Properties of the Persian Version of the Geriatric Sleep Questionnaire (P-Gsq), Cranio - Journal of Craniomandibular and Sleep Practice (2024)
11. Diet Quality Indices Are Associated With Sleep and Mental Health Status Among Diabetic Women: A Cross-Sectional Study, Eating and Weight Disorders (2022)
12. Current Challenges and Opportunities in Global Sleep Medicine, Encyclopedia of Sleep and Circadian Rhythms: Volume 1-6# Second Edition (2023)
13. Association of Sleep Characteristics and Respiratory Symptoms at a Smelting Factory, Work (2022)
14. When Non‐Suicidal Self‐Injury Predicts Non‐Suicidal Self‐Injury and Poor Sleep—Results From a Larger Cross‐Sectional and Quasi‐Longitudinal Study, International Journal of Environmental Research and Public Health (2021)
15. Validity and Reliability of the Dysfunctional Beliefs and Attitudes About Sleep Scale-10 in Iranian Clinical Population, Iranian Journal of Psychiatry and Behavioral Sciences (2018)
16. Glasgow Sleep Effort Scale: Translation, Test, and Evaluation of Psychometric Properties of the Persian Version, Nature and Science of Sleep (2020)
17. Associations Between Sleep Disturbances, Personality Traits and Self-Regulation in a Sample of Healthy Adults, Journal of Clinical Medicine (2024)
18. Effects of Aphrodite (An Herbal Compound) on Ssri-Induced Sexual Dysfunctions and Depression in Females With Major Depressive Disorder: Findings From a Randomized Clinical Trial, Medicina (Lithuania) (2023)
19. Ramadan Observance Exacerbated the Negative Effects of Covid-19 Lockdown on Sleep and Training Behaviors: A International Survey on 1,681 Muslim Athletes, Frontiers in Nutrition (2022)
20. Lockdown Duration and Training Intensity Affect Sleep Behavior in an International Sample of 1,454 Elite Athletes, Frontiers in Physiology (2022)
21. Sleep Microstructure and Clinical Characteristics of Patients With Restless Legs Syndrome, Journal of Clinical Sleep Medicine (2022)
22. Cohort Profile: The Iranian Longitudinal Study on Ageing (Irlsa): The First Comprehensive Study on Ageing in Iran, International Journal of Epidemiology (2022)
23. Covid-19 Lockdowns: A Worldwide Survey of Circadian Rhythms and Sleep Quality in 3911 Athletes From 49 Countries, With Data-Driven Recommendations, Sports Medicine (2022)
24. Evaluation of Sleep Quality and Depressive Symptoms Among Medical Students During Covid-19 Pandemic, Middle East Current Psychiatry (2023)
25. The Association Between Sleep Quality, Health Status and Disability Due to Breathlessness in Chronic Obstructive Pulmonary Disease Patients, Clinical Respiratory Journal (2021)
26. Melatonin Effects in Women With Comorbidities of Overweight, Depression, and Sleep Disturbance: A Randomized Placebo Controlled Clinical Trial, Sleep Medicine Research (2022)
27. The Efficacy of Vitamin B6 As an Adjunctive Therapy to Lithium in Improving the Symptoms of Acute Mania in Patients With Bipolar Disorder, Type 1; a Double-Blind, Randomized, Placebo-Controlled, Clinical Trial, Brain and Behavior (2021)
28. The Effect of Listening to Iranian Pop and Classical Music, on Mental and Physiological Drowsiness, Sleep and Biological Rhythms (2022)
29. Adaptation of the 10-Item Functional Outcomes of Sleep Questionnaire to Iranian Patients With Obstructive Sleep Apnea, Quality of Life Research (2016)
30. Clinical Determinants of Sleep Quality in Patients With Amyotrophic Lateral Sclerosis, Sleep and Breathing (2023)
31. Sleep Quality and Its Association With Psychological Distress and Sleep Hygiene: A Crosssectional Study Among Pre-Clinical Medical Students, Sleep Science (2018)
32. Association of Healthy Beverage Index With Circadian Rhythm and Quality of Sleep Among Overweight and Obese Women: A Cross-Sectional Study, Eating and Weight Disorders (2022)
33. Prevalence and Effects of Sleep Disorders Among Shift-Working Nurse, Annals of Tropical Medicine and Public Health (2018)
34. Sleep Quality in Prisoners With Substance Use Disorder (Sud) in Iran—A Cross-Sectional Study, Journal of Substance Use (2020)
35. Obstructive Sleep Apnea and Excessive Daytime Sleepiness Among Patients With Type 2 Diabetes Mellitus: A Single-Center Study From Iran, International Journal of Diabetes in Developing Countries (2015)
36. Sleep Traits and Associated Factors Among People Living With Hiv/Aids in Iran: A Two-Step Clustering Analysis, Scientific Reports (2024)
37. Sleep Problems, Social Anxiety and Stuttering Severity in Adults Who Do and Adults Who Do Not Stutter, Journal of Clinical Medicine (2023)
38. Memantine for Prophylactic Treatment of Migraine Without Aura: A Randomized Double-Blind Placebo-Controlled Study, Headache (2016)
39. Psychometric Evaluation of Persian Version of Seizure Severity Questionnaire, Epilepsy and Behavior (2022)
40. Evaluation of the Relationship Between Psychological Distress and Sleep Problems With Annoyance Caused by Exposure to Environmental Noise in the Adult Population of Tehran Metropolitan City, Iran, Journal of Environmental Health Science and Engineering (2022)
41. Comparing the Effects of Melatonin and Zolpidem on Sleep Quality, Depression, and Anxiety in Patients With Colorectal Cancer Under Going Chemotherapy, Basic and Clinical Neuroscience (2021)
42. Relationship Between Sleep Quality, Obstructive Sleep Apnea and Sleepiness During Day With Related Factors in Professional Drivers, Acta Medica Iranica (2017)
43. Association Between Mediterranean Dietary Pattern With Sleep Duration, Sleep Quality and Brain Derived Neurotrophic Factor (Bdnf) in Iranian Adults, Scientific Reports (2023)
44. Shift Work Disorder, Insomnia, and Depression Among Offshore Oil Rig Workers, Iranian Journal of Psychiatry (2021)
45. Assessment the Health-Related Quality of Life in Women With Polycystic Ovary Syndrome, Tehran University Medical Journal (2020)
46. The Effect of Auditory Stimulation Using Delta Binaural Beat for a Better Sleep and Post-Sleep Mood: A Pilot Study, Digital Health (2022)
47. Diet in Relation to Metabolic, Sleep and Psychological Health Status (Dimets): Protocol for a Cross-Sectional Study, BMJ Open (2023)
48. Translation, Cultural Adaptation, and Validation of the Sleep Apnea Quality of Life Index (Saqli) in Persian-Speaking Patients With Obstructive Sleep Apnea, Sleep and Breathing (2016)
49. Evaluating the Quality and Duration of Sleep Using Actigraphy in Petroleum Industry Shift Workers, Sleep Health (2020)
50. Better Objective Sleep Was Associated With Better Subjective Sleep and Physical Activity; Results From an Exploratory Study Under Naturalistic Conditions Among Persons With Multiple Sclerosis, International Journal of Environmental Research and Public Health (2020)