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Niosome-Loaded Antifungal Drugs As an Effective Nanocarrier System: A Mini Review Publisher



Osanloo M1 ; Assadpour S2 ; Mehravaran A3, 4 ; Abastabar M5 ; Akhtari J6
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University, Medical Sciences, Fasa, Iran
  2. 2. Stud. Research Committee, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University, Medical Sciences, Sari, Iran
  3. 3. Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University, Medical Sciences, Zahedan, Iran
  4. 4. Department of Parasitology and Mycology, Faculty of Medicine, Zahedan University, Medical Sciences, Zahedan, Iran
  5. 5. Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University, Medical Sciences, Sari, Iran
  6. 6. Health of Plant and Livestock Products Research Center, Department of Medical Nanotechnology, Faculty of Medicine, Mazandaran University, Medical Sciences, Sari, Iran

Source: Current Medical Mycology Published:2018


Abstract

Skin is an important organ of the body due to offering an accessible and convenient site for drug administration. One of the disadvantages of transdermal drug delivery is the low penetration rate of drugs through the skin. Over the past decades, nanoparticles have been used as drug delivery systems to increase therapeutic effects or reduce toxicity. Encapsulation of drugs in nanoparticulate vesicles simplifies the transports of drugs into and across the skin. Niosome nanoparticles are among these drug delivery systems, which have numerous applications in drug delivery and targeting. Niosomes are frequently used for loading drugs serving different purposes (e.g., anticancer, antiviral, and antibacterial agents). In recent years, there has been much research on the use of niosomal systems for the delivery of fungal drugs. A review of the literature investigating the advantages of niosomes in antifungal drug delivery can elucidate the efficiency and superiority of this nanocarrier over other nanocarriers. Copyright© 2018, Published by Mazandaran University of Medical Sciences on behalf of Iranian Society of Medical Mycology and Invasive Fungi Research Center.