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Antiamyloidogenic Effects of Ellagic Acid on Human Serum Albumin Fibril Formation Induced by Potassium Sorbate and Glucose Publisher Pubmed



Taghavi F1, 2 ; Habibirezaei M3 ; Bohlooli M1, 4 ; Farhadi M5 ; Goodarzi M1 ; Movaghati S1 ; Maghami P1 ; Taghibiglou C6 ; Amanlou M7 ; Haertle T8, 9 ; Moosavimovahedi AA1, 10
Authors
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Authors Affiliations
  1. 1. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
  2. 2. Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
  3. 3. School of Biology, University of Tehran, Tehran, Iran
  4. 4. School of Science, University of Zabol, Zabol, Iran
  5. 5. ENT-HNS Research Center, IRAN University of Medical Sciences (IUMS), Tehran, Iran
  6. 6. Department of Pharmacology, College of Medicine, University of Saskatchewan, SK, Canada
  7. 7. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. UR 1268 Biopolymeres Interactions Assemblages, INRA, equipe Fonctions et Interactions des Proteines, Nantes, France
  9. 9. Department of Animal Nutrition and Feed Management, Poznan University of Life Sciences, Poznan, Poland
  10. 10. Center of Excellence in Biothermodynamics, University of Tehran, Tehran, Iran

Source: Journal of Molecular Recognition Published:2016


Abstract

Oxidative stress has the main role in protein conformational changes and consequent direct involvement in different kind of diseases. Potassium sorbate as a widespread industrial preservative and glucose are two important oxidants that can be involved in oxidative stress. In this study the effect of ellagic acid as a phenolic antioxidant on amyloid fibril formation of human serum albumin upon incubation of potassium sorbate and glucose was studied using thioflavin T assay, surface tension, atomic force microscopy, Amadori product, and carbonyl content assays. The thioflavin T assay and atomic force microscopy micrographs demonstrated the antiamyloidogenic effect of ellagic acid on the human serum albumin fibril formation. This antioxidant also had the repair effect on surface tension of the modified human serum albumin (amyloid intermediates), which was destructed, caused by potassium sorbate and glucose. This mechanism takes place because of potent carbonyl stress suppression effect of ellagic acid, which was strengthening by potassium sorbate in the presence and absence of glucose. Copyright © 2016 John Wiley & Sons, Ltd.
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