Tryptophan and Serotonin Levels As Potent Biomarkers in Diabetes Mellitus Complications: A New Approach of Diagnostic Role Publisher



Khoshnevisan K^{1, 2} ; Chehrehgosha M^{3, 4} ; Sajjadijazi SM⁵ ; Meftah AM⁶ Show Affiliations
Source: Journal of Diabetes and Metabolic Disorders Published:2022

Abstract

Objective: Alterations in the serotonergic system were verified to act a role in the pathogenesis of altered neurological and psychiatric diseases. In recent years, Tryptophan (Trp) and serotonin (5-HT) levels have been considered potent biomarkers of diabetes mellitus (DM). Method: The different Trp metabolism may also play roles in the pathogenesis of DM and mounting risk of complications. The whole blood (WB) 5-HT level was mainly lower among diabetic patients compared to others. That is mostly derived from a lower platelet concentration of 5-HT in these patients. Results: Indeed, 5-HT level can be considered a potent biomarker for early detection of DM complications. Besides, it was proved that outside the digestive and central nervous systems, 5-HT was discovered in beta cells, and scientists have been attempting to realize its mechanism of action ever since. Towards to end, the determination methods, biomarker’s role, and approaches of 5-HT and Trp levels were thoroughly investigated in both healthy and diabetic patients with or without complications. Moreover, the association between insulin and 5-HT has been specifically discussed. Conclusions: Our study concluded that Trp and 5-HT levels could be exclusively applied for early diagnosis of DM complications as well as many other complications. Graphical abstract: [Figure not available: see fulltext.] © 2022, The Author(s), under exclusive licence to Tehran University of Medical Sciences.