Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Obesity, Heart Failure, and Obesity Paradox



Hamzeh N1 ; Ghadimi F1 ; Farzaneh R1 ; Hosseini SK1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Tehran University Heart Center Published:2017

Abstract

The incidence and prevalence of obesity are fast increasing worldwide. Various indices have been used to measure and assess obesity. The body mass index (BMI) is the most common and practical of these indices. Overweight and obesity exert considerable adverse effects on the cardiovascular system. These effects are mediated through various neurohormonal and cytokine pathways, most of which are inflammatory mediators. Systolic and/or diastolic heart failure is more prevalent among obese and overweight individuals than among normal weight people. The concept of the “obesity paradox” has been proposed by some previously published studies, in which the prognosis of obese patients with established cardiovascular diseases, especially heart failure, is better than that of their leaner counterparts. In this review, we discuss the obesity paradox and its possible pathophysiologic mechanisms. © 2017, Tehran Heart Center. All rights reserved.
Related Docs
1. Pre- and Post-Diagnosis Body Mass Index and Heart Failure Mortality: A Dose–Response Meta-Analysis of Observational Studies Reveals Greater Risk of Being Underweight Than Being Overweight, Obesity Reviews (2019)
2. Maximal Oxygen Consumption Is Positively Associated With Resting Metabolic Rate and Better Body Composition Profile, Obesity Medicine (2021)
3. Obesity Paradox in Advanced Kidney Disease: From Bedside to the Bench, Progress in Cardiovascular Diseases (2018)
4. Changes in Obesity Odds Ratio Among Iranian Adults, Since 2000: Quadratic Inference Functions Method, Computational and Mathematical Methods in Medicine (2016)
5. Renal Cell Carcinoma Survival and Body Mass Index: A Dose-Response Meta-Analysis Reveals Another Potential Paradox Within a Paradox, International Journal of Obesity (2016)
6. Longitudinal Association Between Body Mass Index and Physical Activity Among Adolescents With Different Parental Risk: A Parallel Latent Growth Curve Modeling Approach, International Journal of Behavioral Nutrition and Physical Activity (2020)
7. A Dose-Response Meta-Analysis of the Impact of Body Mass Index on Stroke and All-Cause Mortality in Stroke Patients: A Paradox Within a Paradox, Obesity Reviews (2015)
8. Nonlinear Dose–Response Association Between Body Mass Index and Risk of All-Cause and Cardiovascular Mortality in Patients With Hypertension: A Meta-Analysis, Obesity Research and Clinical Practice (2018)
Experts (# of related papers)
View all Related Experts
Sakineh Shab-Bidar (4)
Kurosh Djafarian (3)