Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
In Vitro Antifungal Activity of Novel Triazole Efinaconazole and Five Comparators Against Dermatophyte Isolates Publisher Pubmed



Rezaeimatehkolaei A1 ; Khodavaisy S2 ; Alshahni MM3, 4 ; Tamura T3, 4 ; Satoh K3, 4 ; Abastabar M5 ; Shokoohi GR6 ; Ahmadi B7 ; Kord M2 ; Taghipour S1 ; Makimura K3, 4 ; Badalie H8
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Medical Mycology, School of Medicine, Health Research Institute, Infectious and TropicalDiseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  2. 2. Department of Medical Mycology and Parasitology, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. General Medical Education and Research Center, Teikyo University, Tokyo, Japan
  4. 4. Teikyo University Institute of Medical Mycology, Tokyo, Japan
  5. 5. Department of Medical Mycology/Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Department of Parasitology and Mycology, School of Medicine, Jahrom University of Medical Sciences, Jahrom, Iran
  7. 7. Department of Medical Laboratory Sciences, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran
  8. 8. Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran

Source: Antimicrobial Agents and Chemotherapy Published:2018


Abstract

The objective of this study was to assess the in vitro activity of the novel triazole antifungal drug, efinaconazole, and five comparators (luliconazole, lanoconazole, terbinafine, itraconazole, and fluconazole) against a large collection of Trichophyton interdigitale and Trichophyton rubrum clinical isolates. The geometric mean MICs were the lowest for luliconazole (0.0005 g/ml), followed by lanoconazole (0.002 g/ml), efinaconazole (0.007 g/ml), terbinafine (0.011 g/ml), itraconazole (0.095 g/ml), and fluconazole (12.77 g/ml). It appears that efinaconazole, lanoconazole, and luliconazole are promising candidates for the treatment of dermatophytosis due to T. interdigitale and T. rubrum. Copyright © 2018 American Society for Microbiology. All Rights Reserved.
Related Docs
View other Related Docs
1. Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole Against a Collection of Azole-Resistant and -Susceptible Aspergillus Fumigatus Strains, Antimicrobial Agents and Chemotherapy (2016)
2. Comparison of in Vitro Antifungal Activity of Novel Triazoles With Available Antifungal Agents Against Dermatophyte Species Caused Tinea Pedis, Journal de Mycologie Medicale (2020)
3. Trichophyton Mentagrophytes and T Interdigitale Genotypes Are Associated With Particular Geographic Areas and Clinical Manifestations, Mycoses (2019)
4. In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared With Those of Five Antifungal Drugs Against Melanized Fungi and Relatives, Antimicrobial Agents and Chemotherapy (2017)
5. Potent Activities of Luliconazole, Lanoconazole, and Eight Comparators Against Molecularly Characterized Fusarium Species, Antimicrobial Agents and Chemotherapy (2018)
6. In-Vitro Antifungal Susceptibility Testing of Lanoconazole and Luliconazole Against Aspergillus Flavus As an Important Agent of Invasive Aspergillosis, Journal of Infection and Chemotherapy (2019)
7. In Vitro Activities of 15 Antifungal Drugs Against a Large Collection of Clinical Isolates of Microsporum Canis, Mycoses (2019)
8. Characterizing the Clinical Isolates of Dermatophytes in Hamadan City, Central West of Iran, Using Pcr-Rlfp Method, Journal de Mycologie Medicale (2018)
Experts (# of related papers)
View all Related Experts
Sadegh Khodavaisy (4)
Roshanak Daei Ghazvini (3)
Other Related Docs
9. Use of Restriction Fragment Length Polymorphism to Rapidly Identify Dermatophyte Species Related to Dermatophytosis, Jundishapur Journal of Microbiology (2015)
10. Molecular Characterization and Antifungal Susceptibility Profile of Dermatophytes Isolated From Scalp Dermatophyte Carriage in Primary School Children in Arak City, Center of Iran, Journal de Mycologie Medicale (2019)
11. Familial Cases of Trichophyton Benhamiae Infection Transmitted From a Guinea Pig in Iran, Mycopathologia (2021)
12. Comparison of in Vitro Activities of Newer Triazoles and Classic Antifungal Agents Against Dermatophyte Species Isolated From Iranian University Hospitals: A Multi-Central Study, Annals of Clinical Microbiology and Antimicrobials (2023)
13. Pesticide Behavior in Paddy Fields and Development of Azole-Resistant Aspergillus Fumigatus: Should We Be Concerned?, Journal de Mycologie Medicale (2018)
14. In Vitro Antifungal Susceptibility Profile of Iranian Fusarium Isolates: Emphasising on the Potent Inhibitory Effect of Efinaconazole Compared to Other Drugs, Mycoses (2023)
15. Efinaconazole Topical Solution 10%: Formulation and Efficacy Assessment in the Treatment of Toenail Onychomycosis, Mycoses (2020)
16. In Vitro Antifungal Activity of Green Synthesized Silver Nanoparticles in Comparison to Conventional Antifungal Drugs Against Trichophyton Interdigitale, Trichophyton Rubrum and Epidermophyton Floccosum, Infectious Disorders - Drug Targets (2021)
17. Specific Identification and Antifungal Susceptibility Pattern of Clinically Important Dermatophyte Species Isolated From Patients With Dermatophytosis in Tehran, Iran, Archives of Clinical Infectious Diseases (2018)
18. Drug Sensitivity Profile of Fungi Isolated From Onychomycosis Patients and Evaluation of Squalene Epoxidase Mutation in One Terbinafine-Resistant Trichophyton Mentagrophytes Species, Microbial Drug Resistance (2021)