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Potent Activities of Novel Imidazoles Lanoconazole and Luliconazole Against a Collection of Azole-Resistant and -Susceptible Aspergillus Fumigatus Strains Publisher Pubmed



Abastabar M1 ; Rahimi N2 ; Meis JF3, 4 ; Aslani N2 ; Khodavaisy S5 ; Nabili M1 ; Rezaeimatehkolaei A6 ; Makimura K7 ; Badali H1, 8
Authors
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Authors Affiliations
  1. 1. Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Department of Medical Microbiology and Infectious Diseases, Canisius-Wilhelmina Hospital, Nijmegen, Netherlands
  4. 4. Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
  5. 5. Department of Medical Mycology and Parasitology, Tehran University of Medical Science, Tehran, Iran
  6. 6. Health Research Institute, Infectious and Tropical Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  7. 7. Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Japan/Asia International Institute of Infectious Diseases Control, Teikyo University Institute of Medical Mycology, Tokyo, Japan
  8. 8. Department of Medical Mycology and Parasitology, Mazandaran University of Medical Sciences, Sari, Iran

Source: Antimicrobial Agents and Chemotherapy Published:2016


Abstract

A collection of azole-susceptible (n = 141) and azole-resistant (n = 27) Aspergillus fumigatus isolates was tested against seven antifungal drugs, including the new imidazoles lanoconazole and luliconazole. The luliconazole and lanoconazole MIC90 values for the azole-susceptible strains were 0.001 μg/ml and 0.008 μg/ml, and those for the azole-resistant strains were 0.016 μg/ml and 0.032 μg/ml. Copyright © 2016, American Society for Microbiology. All Rights Reserved.
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