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The Effect of a Hydrolyzed Collagen-Based Supplement on Wound Healing in Patients With Burn: A Randomized Double-Blind Pilot Clinical Trial Publisher Pubmed



Bagheri Miyab K1 ; Alipoor E2 ; Vaghardoost R3 ; Saberi Isfeedvajani M3 ; Yaseri M4 ; Djafarian K1 ; Hosseinzadehattar MJ1, 5
Authors
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Authors Affiliations
  1. 1. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Burn Research Center, Department of Plastic and Reconstructive Surgery, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Centre of Research Excellence in Translating Nutritional Science to Good Health, University of Adelaide, Adelaide, Australia

Source: Burns Published:2020


Abstract

Introduction: Burn is among the most severe forms of critical illness, associated with extensive and prolonged physical, metabolic and mental disorders. The aim of this study was to assess the effect of an oral, low-cost, and accessible collagen-based supplement on wound healing in patients with burn. Methods: In this randomized double-blind controlled pilot clinical trial, 31 men, 18–60 years, with 20–30% total body surface area burn were studied. Patients were randomly assigned to receive either a collagen-based supplement (1000 kcal) or an isocaloric placebo, for 4 weeks. Serum pre-albumin, rate of wound healing, length of hospital stay, and anthropometries were assessed at baseline, and the end of week 2 and 4. Results: Serum pre-albumin was significantly higher at week 2 (29.7 ± 13.6 vs. 17.8 ± 7.5 mg/dL, P = 0.006) and week 4 (35.1 ± 7.6 vs. 28.3 ± 8.2 mg/dL, P = 0.023) in collagen than control group. Changes in pre-albumin concentration were also significantly higher in collagen group at week 2 (13.9 ± 9.8 vs. −1.9 ± 10.3 mg/dL, P < 0.001) and week 4 (19.2 ± 7.5 vs. 8.5 ± 10.1 mg/dL, P = 0.002). The Hazard ratio of wound healing was 3.7 times in collagen compared to control group (95% CI: 1.434–9.519, P = 0.007). Hospital stay was clinically, but not statistically, lower in collagen than control group (9.4 ± 4.6 vs. 13.5 ± 7 days, P = 0.063). There were no significant differences in weight, body mass index, dietary energy and protein intakes between the two groups. Conclusion: The findings showed that a hydrolyzed collagen-based supplement could significantly improve wound healing and circulating pre-albumin, and clinically reduce hospital stay in patients with 20–30% burn. © 2019 Elsevier Ltd and ISBI
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