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Nanotechnology-Driven Egcg: Bridging Antioxidant and Therapeutic Roles in Metabolic and Cancer Pathways Publisher Pubmed



Esmaeili Z1 ; Shavali Gilani P2 ; Khosravani M1 ; Motamedi M1 ; Maleknejad S3 ; Adabi M1, 4 ; Sadighara P2
Authors
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Authors Affiliations
  1. 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Environmental Health Engineering, Division of Food Safety and Hygiene, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
  4. 4. Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Nanomedicine Published:2025


Abstract

Epigallocatechin-3-gallate (EGCG), the primary polyphenol in green tea, is renowned for its potent antioxidant properties. EGCG interacts with various cellular targets, inhibiting cancer cell proliferation through apoptosis and cell cycle arrest induction, while also modulating metabolic pathways. Studies have demonstrated its potential in addressing cancer development, obesity, and diabetes. Given the rising prevalence of metabolic diseases and cancers, EGCG is increasingly recognized as a promising therapeutic agent. This review provides a comprehensive overview of the latest findings on the effects of both free and nano-encapsulated EGCG on mechanisms involved in the management and prevention of hyperlipidemia, diabetes, and gastrointestinal (GI) cancers. The review highlights EGCG role in modulating key signaling pathways, enhancing bioavailability through nano-formulations, and its potential applications in clinical settings. © 2025 Informa UK Limited, trading as Taylor & Francis Group.
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