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Curcumin and Its Novel Formulations for the Treatment of Hepatocellular Carcinoma: New Trends and Future Perspectives in Cancer Therapy Publisher



Meybodi SM1 ; Rezaei P2 ; Faraji N3 ; Jamehbozorg K4 ; Ashna S5 ; Shokri F6 ; Goleij P7, 8, 9 ; Moradi S10 ; Kashian M11 ; Arefnezhad R12, 13 ; Sahebkar A14, 15
Authors
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Authors Affiliations
  1. 1. Department of Veterinary Medicine, Tabriz Branch, Islamic Azad University, Tabriz, Iran
  2. 2. Student Research Committee, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Converging Sciences and Technologies, Science and Research Branch of Islamic, Azad University, Tehran, Iran
  4. 4. Student Research Committee, Hamedan University of Medical Science, Hamedan, Iran
  5. 5. Student Research Committee, Islamic Azad University Science and Research Branch, Tehran, Iran
  6. 6. Student Research Committee, Tehran Azad University of Medical Sciences, Tehran, Iran
  7. 7. Department of Genetics, Faculty of Biology, Sana Institute of Higher Education, Sari, Iran
  8. 8. PhytoPharmacology Interest Group (PPIG), Universal Scientific Education and Research, Network (USERN), Tehran, Iran
  9. 9. USERN Office, Kermanshah University of Medical Sciences, Kermanshah, Iran
  10. 10. Student Research Committee, University of Science and Culture, Tehran, Iran
  11. 11. Student Research Committee, Iran University of Medical Sciences, Tehran, Iran
  12. 12. Coenzyme R Research Institute, Tehran, Iran
  13. 13. Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
  14. 14. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  15. 15. Applied Biomedical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Journal of Functional Foods Published:2023


Abstract

Hepatocellular carcinoma (HCC), as a common malignancy of the liver, is the second leading cause of cancer-related death in the world and mostly occurs in patients with a background of chronic liver disease. Patents with this carcinoma represent various signs and symptoms, such as splenomegaly, peripheral edema, and jaundice. More than 70 % of HCC cases are in the advanced stage because of lacking the diagnostic systems and indications in the early stages, therefore giving rise to a high lethality rate in involved patients. Against this malignancy, several therapeutic methods have been recommended, like surgical resection, immunotherapy, liver transplantation, and chemotherapeutic drugs (e.g., doxorubicin, mitomycin C, and cisplatin); however, these curative modalities have not created a serious hope for HCC patents. Nowadays, herbal medicine with natural compounds has been offered for different illnesses, such as cancer. Among these, some herbal components and their nano-based formulations, especially curcumin (a polyphenol extract of Curcuma longa), have become a point of interest in treating HCC. Hence, this review aimed to evaluate the anticancer effects of curcumin and its biological potential for treating HCC based on the current documents. © 2023 The Author(s)
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