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A Review on Synthesis, Mechanism of Action, and Structure-Activity Relationships of 1,2,3-Triazole-Based Α-Glucosidase Inhibitors As Promising Anti-Diabetic Agents Publisher



Fallah Z1 ; Tajbakhsh M1 ; Alikhani M2 ; Larijani B3 ; Faramarzi MA4 ; Hamedifar H5 ; Mohammadikhanaposhtani M6 ; Mahdavi M3
Authors
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Authors Affiliations
  1. 1. Faculty of Chemistry, University of Mazandaran, P. O. Box 47416, Babolsar, 95447, Iran
  2. 2. Department of Internal Medicine, School of Medicine, Rheumatology Research Center Shariati Hospital, Tehran University of Medical Sciences, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, P. O. Box 14117, 13137, Tehran, Iran
  4. 4. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, P. O. Box 47176, Babol, 47745, Iran

Source: Journal of Molecular Structure Published:2022


Abstract

α-Glucosidase is a key enzyme in hydrolysis of carbohydrates to glucose and located in the small intestine brush border. Inhibition of this enzyme delay the release of glucose and therefore α-glucosidase inhibitors are considered as attractive drugs for treatment of diabetes as a carbohydrate-related disorder. Due to the importance of α-glucosidase inhibitors in the treatment of diabetes, the discovery and development of new safe and efficient inhibitors for α-glucosidase is an attractive topic for medicinal chemists. In the last decade, 1,2,3-triazole-based derivatives have found much interest in this research field. The click reaction is the most potent tool for easy construction for synthesis of hybrid molecules of 1,2,3-triazole ring and other effective pharmacophors in α-glucosidase inhibition. Herein, an overview is reported on synthesis, biological evaluations, and structure-activity relationships of the reported α-glucosidase inhibitors containing 1,2,3-triazole ring. © 2022 Elsevier B.V.
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