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Intramolecular Click Cycloaddition Reactions: Synthesis of 1,2,3-Triazoles Publisher Pubmed



Tashrifi Z1 ; Mohammadi Khanaposhtani M2 ; Bahadorikhalili S3 ; Larijani B1 ; Mahdavi M1
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Authors Affiliations
  1. 1. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Faculty of Fouman, College of Engineering, University of Tehran, Fou-man, Iran
  3. 3. Department of Electronic Engineering, Universitat Rovira i Virgili, Tarragona, 43007, Spain

Source: Current Organic Synthesis Published:2024


Abstract

Click Chemistry, as a powerful tool, has been used for the synthesis of a variety of 1,2,3-triazoles. Among click cycloaddition reactions, intramolecular click reactions carried out in azido-alkyne precursors has not been thoroughly reviewed. Hence, in this review, we have sum-marized and categorised the recent literature (from 2012 on) based on the azidoalkynyl precursor's type and a brief and concise description of the involved mechanisms is presented. Accordingly, we have classified the relevant literature into three categories: (1) substitution precursors (2) addition and (3) multi-component reaction (MCR) products. © 2024 Bentham Science Publishers.
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