Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Unravelling Toxoplasma Treatment: Conventional Drugs Toward Nanomedicine Publisher Pubmed



Jafarpour Azami S1, 2 ; Mohammad Rahimi H1 ; Mirjalali H1 ; Zali MR3
Authors
Show Affiliations
Authors Affiliations
  1. 1. Foodborne and Waterborne Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: World Journal of Microbiology and Biotechnology Published:2021


Abstract

Abstract: Toxoplasma gondii is a worldwide protozoan parasite that infects almost all warm-blooded animals. Although human toxoplasmosis is mostly latent, pregnant women and immunocompromised patients need effective treatment. There are drugs of choice for treatment of toxoplasmosis; however, due to their side effects and/or their disease stage-specificity, prescription of them is limited. During recent years, nanomedicine has been employed to overcome limitations of conventional drugs. Here, we provided a state-of-the-art review of experimental toxoplasmosis treatment using nanotechnology. Graphic abstract: [Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Nature B.V. part of Springer Nature.
Related Docs
View other Related Docs
1. Nanoemulsion of Atovaquone As a Promising Approach for Treatment of Acute and Chronic Toxoplasmosis, European Journal of Pharmaceutical Sciences (2018)
2. Nanoemulsion of Spiramycin Against Tachyzoites of Toxoplasma Gondii, Rh Strain: Preparation, Toxicology, and Efficacy Studies, Iranian Journal of Public Health (2023)
3. Formulation and Evaluation of Atovaquone-Loaded Macrophage-Derived Exosomes Against Toxoplasma Gondii: In Vitro and in Vivo Assessment, Microbiology Spectrum (2024)
4. Anti-Toxoplasma Activity of Various Molecular Weights and Concentrations of Chitosan Nanoparticles on Tachyzoites of Rh Strain, International Journal of Nanomedicine (2018)
5. Curcumin Nanoemulsion As a Novel Chemical for the Treatment of Acute and Chronic Toxoplasmosis in Mice, International Journal of Nanomedicine (2018)
6. The Therapeutic Efficacy of Zinc Oxide Nanoparticles on Acute Toxoplasmosis in Balb/C Mice, Iranian Journal of Parasitology (2023)
7. Protoscolicidal Effects of Curcumin Nanoemulsion Against Protoscoleces of Echinococcus Granulosus, BMC Complementary Medicine and Therapies (2023)
8. Nanosilver Colloid Inhibits Toxoplasma Gondii Tachyzoites and Bradyzoites in Vitro, Iranian Journal of Parasitology (2019)
Experts (# of related papers)
View all Related Experts
Saeedeh Shojaee (15)
Hossein Keshavarz Valian (15)
Other Related Docs
9. Biogenic Selenium Nanoparticles Target Chronic Toxoplasmosis With Minimal Cytotoxicity in a Mouse Model, Journal of Medical Microbiology (2020)
10. Prevalence of Toxoplasmosis in Natural Ungulates As Human Zoonotic Meat-Borne Pathogens: A Systematic Review and Meta-Analysis, Journal of Food Science (2025)
11. In Vitro and in Vivo Anti-Parasitic Activity of Biogenic Antimony Sulfide Nanoparticles on Leishmania Major (Mrho/Ir/75/Er), Parasitology Research (2019)
12. A Review Study About the Effect of Chitosan Nanocarrier on Improving the Efficacy of Amphotericin B in the Treatment of Leishmania From 2010 to 2020, Current Drug Delivery (2021)
13. Seroepidemiology and Risk Factors of Toxoplasmosis Among Children Age Ranged From 1 to 14 Years Referred to Medical Diagnostic Laboratories in Southeast Iran, Clinical Epidemiology and Global Health (2020)
14. Assessment of the Immunogenicity and Protective Efficiency of a Novel Dual-Promoter Dna Vaccine, Harboring Sag1 and Gra7 Genes, From Rh Strain of Toxoplasma Gondii in Balb/C Mice, Infection and Drug Resistance (2019)
15. Chronic Toxoplasma Gondii Infection Potentiates Parkinson’S Disease Course in Mice Model, Iranian Journal of Parasitology (2021)
16. Toxicology of Nanobiomaterials, Stem Cell Nanoengineering (2015)
17. Where Do We Stand? Insight on Patented Products and Those Under Clinical Trials, Advances in Antiparasitic Therapies and Drug Delivery (2023)
18. Development, Optimization, and Validation of an In-House Dot-Elisa Rapid Test Based on Sag1 and Gra7 Proteins for Serological Detection of Toxoplasma Gondii Infections, Infection and Drug Resistance (2019)
19. Overview of Apoptosis, Autophagy, and Inflammatory Processes in Toxoplasma Gondii Infected Cells, Pathogens (2023)
20. The Relation of Secondary Sex Ratio and Miscarriage History With Toxoplasma Gondii Infection, BMC Infectious Diseases (2018)
21. The Relation of Serum Prolactin Levels and Toxoplasma Infection in Humans, International Journal of General Medicine (2019)
22. Does Pharmacodynamics of Drugs Change After Presenting Them As Na-Noparticles Like Their Pharmacokinetics?, Current Drug Targets (2020)
23. Effects of Silver Nanoparticles on Human Health, European Journal of Nanomedicine (2015)
24. Role of Toxoplasma Gondii Igg Avidity Testing in Discriminating Between Acute and Chronic Toxoplasmosis in Pregnancy, Journal of Clinical Microbiology (2020)
25. An Investigation of Electrospun Henna Leaves Extract-Loaded Chitosan Based Nanofibrous Mats for Skin Tissue Engineering, Materials Science and Engineering C (2017)
26. A Review on the Use of Essential Oil-Based Nanoformulations in Control of Mosquitoes, Biointerface Research in Applied Chemistry (2021)
27. Toxoplasma Gondii Vaccine Candidates: A Concise Review, Irish Journal of Medical Science (2023)
28. Fighting Parasites During the Post-Antibiotic Era, Advances in Antiparasitic Therapies and Drug Delivery (2023)
29. Traditional Medicine and Natural Products As Antiparasitic Agents, Advances in Antiparasitic Therapies and Drug Delivery (2023)
30. Melittin As a Promising Anti-Protozoan Peptide: Current Knowledge and Future Prospects, AMB Express (2021)
31. Design of a Dual-Promoter Expression Vector Harboring Sag1 and Gra7 Genes From Toxoplasma Gondii (Rh Strain), Tropical Biomedicine (2018)
32. Anti-Rheumatic Activity of Topical Nanoemulsion Containing Bee Venom in Rats, European Journal of Pharmaceutics and Biopharmaceutics (2022)
33. Necrotic, Apoptotic and Autophagic Cell Fates Triggered by Nanoparticles, Autophagy (2019)
34. Infections, Inflammation, and Risk of Neuropsychiatric Disorders: The Neglected Role of “Co-Infection”, Heliyon (2020)
35. Particularly Neglected in Countries With Other Challenges: High Toxoplasma Gondii Seroprevalence in Pregnant Women in Kabul, Afghanistan, While a Low Proportion Know About the Parasite, PLoS ONE (2019)
36. The Association of Latent Toxoplasmosis and Level of Serum Testosterone in Humans, BMC Research Notes (2018)