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Prevalence of Cotrimoxazole Resistance Uropathogenic Bacteria in Iran: A Systematic Review and Meta-Analysis Publisher



Rezaee M1 ; Ghafourian S2 ; Sayehmiri F2 ; Pakzad R3, 4 ; Safiri S5, 6 ; Pakzad I2, 7
Authors
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Authors Affiliations
  1. 1. Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
  3. 3. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
  4. 4. Department of Epidemiology, Faculty of Health, Ilam University of Medical Sciences, Ilam, Iran
  5. 5. Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran

Source: Archives of Clinical Infectious Diseases Published:2018


Abstract

Context: Cotrimoxazole is one of the antibiotics commonly used to treat urinary tract infections. The widespread use of this drug has led to increased resistance to cotrimoxazole among urinary tract pathogens. This study aimed to investigate the cotrimoxazole resistance pattern of uropathogenic bacteria by a systematic review and meta-analysis method. Evidence Acquisition: Several databases including PubMed, Web of Science, Scopus, Google Scholar, Iran Medex, Magiran, IranDoc, MedLib, and SID were searched. From a total of 171 papers published from different regions of Iran from 1992 to May 2015, 67 were included in this study. To assess the quality of the study, the STROBE (strengthening the reporting of observational studies in epi-demiology) checklist was employed. The I2 index was used to determine heterogeneity and a random effects model to analyze the data. Results: The results showed that the prevalence of urinary tract infection was several times higher in women than in men. The most common pathogens causing urinary tract infections were E. coli 64%, Klebsiella 12%, Staphylococcus 10%, and Enterobacter (6%). The prevalence of cotrimoxazole resistance was as follows: E. coli 62% (95%CI: 60-65), Klebsiella 54% (95% CI: 45-62), Staphylococcus 55% (95% CI: 47-63), and Enterobacter 52% (95% CI: 33-70). Cotrimoxazole resistance in different studies varied from 22% in Arak to 88% in Ahvaz. Conclusions: Gram-negative bacilli, particularly Escherichia coli, were the most common bacteria causing urinary tract infections. The majority of strains were resistant to cotrimoxazole. According to the findings, cotrimoxazole is not recommended as the first-line drug for the treatment of urinary tract infections in Iran. © 2018, Archives of Clinical Infectious Diseases.
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