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Frequency of Bacteria Causing Urinary Tract Infection and Their Antibiotic Resistance Among Children Publisher



Rafati S1 ; Tavousian R2 ; Davati A3 ; Afshin A4 ; Attarpour Yazdi M5 ; Soltanipur M2, 6 ; Shahshenas S2
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Authors Affiliations
  1. 1. Department of Pediatric, Faculty of Medicine, Shahed University, Tehran, Iran
  2. 2. Medical Students Research Committee, Shahed Universit, Tehran, Iran
  3. 3. Department of Social Medicine, Faculty of Medicine, Shahed University, Tehran, Iran
  4. 4. Department of Pediatric Nephrology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Microbiolog, Facultof Medicine, Shahed Universit, Tehran, Iran
  6. 6. Department of Quality of Life, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Shiraz E Medical Journal Published:2024


Abstract

Background: Childhood urinary tract infections (UTIs) are among the most prevalent diseases. In recent years, the overuse of common antibiotics has increased antibiotic resistance among urinary tract pathogens worldwide, with changes in the pattern of microbial resistance varying by geographical area and time. Objectives: This study aims to investigate the pattern of microbial resistance of UTI pathogens in pediatric patients. Methods: In this cross-sectional study, children aged < 13 years with UTI and positive urine cultures, who were admitted to Bahrami Hospital in Tehran, Iran, between 2015 and 2019, were evaluated. The pathogens' frequency, their antimicrobial resistance, and clinical and demographic information were extracted from the patients' files. Statistical relationships between clinical and demographic data and antibiotic resistance were analyzed using appropriate statistical tests. Results: The files of 202 patients were evaluated. The majority of patients were female (79.2%). UTI was more common among the 12-60 months age group (36.3%) in females and the 1-12 months age group (50%) in males. The most common UTI pathogen was Escherichia coli (85.1%). The lowest rates of microbial resistance were related to Meropenem (0% resistance), Gentamicin (9.2%), and Amikacin (10.8%). Conversely, the highest resistance rates were observed for Cotrimoxazole (74.6%), Ampicillin (74.5%), and Cephalothin (64.9%). Conclusions: UTI is more common in females aged 1 to 60 months. E. coli is the most common cause of UTI. Microbial resistance to antibiotics used for empirical treatment, such as ceftriaxone, is high and changes over time. It is recommended to use alternative antibiotics and avoid the inappropriate administration of antibiotics. © 2024, Rafati et al.
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