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Prevention Strategies to Minimize the Infection Risk Associated With Biologic and Targeted Immunomodulators Publisher



Kordzadehkermani E1 ; Khalili H1 ; Karimzadeh I2 ; Salehi M3
Authors
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Authors Affiliations
  1. 1. Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
  3. 3. Department of Infectious Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Infection and Drug Resistance Published:2020


Abstract

The introduction of biologic and targeted immunomodulators is a significant breakthrough in the therapeutic area of various fields of medicine. The occurrence of serious infections, a complication of secondary immunosuppression associated with these agents, leads to increased morbidity and mortality. Implementing preventive strategies could minimize infection-related complications and improve therapeutic outcomes. The purpose of this review is to focus on current evident approaches regarding screening, monitoring, preventing (immunization and chemoprophylaxis), and management of infections in patients who are candidates for about 70 biologic and targeted immunomodulators. Recommendations are based on relevant guidelines, especially the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document series published in 2018. © 2020 Kordzadeh-Kermani et al.