Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening

Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening Publisher Pubmed

Zafari P^{1, 2} ; Golpour M³ ; Hafezi N¹ ; Bashash D⁴ ; Esmaeili SA^{5, 6} ; Tavakolinia N⁷ ; Rafiei A¹

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1. Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
2. Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
3. Molecular and Cellular Biology Research Center, Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
4. Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
6. Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
7. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: IUBMB Life Published:2021

Abstract

Rheumatoid arthritis (RA) is known to be related to an elevated risk of infections because of its pathobiology and the use of immunosuppressive therapies. Reactivation of latent tuberculosis (TB) infection is a serious issue in patients with RA, especially after receiving anti-TNFs therapy. TNF blocking reinforces the TB granuloma formation and maintenance and the growth of Mycobacterium tuberculosis (Mtb). After intercurrent of TB infection, the standard recommendation is that the treatment with TNF inhibitors to be withheld despite its impressive effect on suppression of inflammation until the infection has resolved. Knowing pathways and mechanisms that are common between two diseases might help to find the mechanistic basis of this comorbidity, as well as provide us a new approach to apply them as therapeutic targets or diagnostic biomarkers. Also, screening for latent TB before initiation of an anti-TNF therapy can minimize complications. This review summarizes the shared gene signature between TB and RA and discusses the biomarkers for early detection of this infection, and screening procedures as well. © 2020 International Union of Biochemistry and Molecular Biology

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Style	Citing Format
MLA	Zafari P, et al.. "Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening." IUBMB Life, vol. 73, no. 1, 2021, pp. 26-39.
APA	Zafari P, Golpour M, Hafezi N, Bashash D, Esmaeili SA, Tavakolinia N, Rafiei A (2021). Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening. IUBMB Life, 73(1), 26-39.
Chicago	Zafari P, Golpour M, Hafezi N, Bashash D, Esmaeili SA, Tavakolinia N, Rafiei A. "Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening." IUBMB Life 73, no. 1 (2021): 26-39.
Harvard	Zafari P et al. (2021) 'Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening', IUBMB Life, 73(1), pp. 26-39.
Vancouver	Zafari P, Golpour M, Hafezi N, Bashash D, Esmaeili SA, Tavakolinia N, et al.. Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening. IUBMB Life. 2021;73(1):26-39.
BibTex	@article{ author = {Zafari P and Golpour M and Hafezi N and Bashash D and Esmaeili SA and Tavakolinia N and Rafiei A}, title = {Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening}, journal = {IUBMB Life}, volume = {73}, number = {1}, pages = {26-39}, year = {2021} }
RIS	TY - JOUR AU - Zafari P AU - Golpour M AU - Hafezi N AU - Bashash D AU - Esmaeili SA AU - Tavakolinia N AU - Rafiei A TI - Tuberculosis Comorbidity With Rheumatoid Arthritis: Gene Signatures, Associated Biomarkers, and Screening JO - IUBMB Life VL - 73 IS - 1 SP - 26 EP - 39 PY - 2021 ER -

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