Analyzing Quality of Life After Low Anterior Resection for Rectal Cancer Publisher Pubmed



Yazd SMM^{1, 2} ; Shahriarirad R^{3, 4} ; Almasi S^{1, 2} ; Naddaffard D⁴ ; Sheikhi S⁵ ; Mosayebi I⁶ ; Goudarzi K⁴ ; Tafti SMA^{1, 2} ; Behboudi B^{1, 2} ; Kazemeini A^{1, 2} ; Keramati MR^{1, 2}
Source: Irish Journal of Medical Science Published:2024

Abstract

Background: Rectal cancer is one of the most common cancers worldwide that imposes high costs on patients and the healthcare system while also having a significant impact on the patient’s quality of life (QoL). Aim: We aimed to assess the QoL of rectal cancer patients undergoing lower anterior resection (LAR) and evaluate potential confounding factors. Methods: In this cross-sectional study, we included patients undergoing neo-adjuvant chemotherapy followed by LAR, diverting ileostomy, and adjuvant chemotherapy. Six months after stoma reversal, QoL was assessed using a cancer-specific core questionnaire EORTC QLQ-C30 and also a colorectal cancer module EORTC QLQ-CR29. Linear and quantile regression models were used to examine associations of QoL and patients’ demographical and clinical features. Results: The study population comprised 210 patients with an average age of 61.9 ± 11.0 (range: 37–85) and 112 (53.3%) male patients. The higher tumor stage increases the QoL of patients by reducing diarrhea, loss of appetite, defecation problems, and stool frequency. Based on the linear regression analysis, a farther distance of the anastomosis from the anal verge (AV) was correlated with lower symptom scores and higher QoL. Also, at the 75th percentile cut-off of the QLQ-CR29 scores, a higher N stage of the tumor was correlated with higher QoL based on functional subscale (coefficient = 3.032, P = 0.016). Conclusions: QoL of patients after LAR for rectal cancer is significantly associated with the distance of the anastomosis site from the AV. © The Author(s), under exclusive licence to Royal Academy of Medicine in Ireland 2024.