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The Potential Effect of Blueberry on Cognitive Health and Mood State Based on Human Intervention Studies: Systematic Review and Mini Meta-Analysis Publisher Pubmed



Soveid N1 ; Barkhidarian B2 ; Moradi S3, 4 ; Gholami F1 ; Rasaei N1 ; Himmerich H5 ; Mirzaei K1
Authors
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Authors Affiliations
  1. 1. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
  2. 2. Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Halal Research Center of IRI, FDA, Tehran, Iran
  4. 4. Nutritional Sciences Department, School of Nutritional Sciences and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran
  5. 5. Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom

Source: CNS and Neurological Disorders - Drug Targets Published:2023


Abstract

Background: Blueberries are known for their high content of several bioactive compounds, specifically anthocyanin, which are the most beneficial of the flavonoid family in terms of neuropro-tection. Several human interventional studies have been conducted to assess the effects of blueberry intake on cognitive performance; however, the results of clinical trials are inconclusive. Therefore, this systematic review and meta-analysis evaluated the effect of blueberry supplementation on some aspects of cognitive performance and mood parameters using data from clinical trials based on existing evidence. Methods: Relevant studies, published in April 2021, were searched through PubMed/Medline, Scopus, Embase, and Google Scholar. The random effect size was used to estimate the pooled effect size. Heterogeneity between studies was evaluated by the Cochrane Q test and I-squared (I2). To detect the potential source of heterogeneity, a subgroup analysis was conducted. Results: Fourteenrandomized trials were included in the quantitative analysis, and six were pooled for statistical analysis. Blueberry intervention resulted in no significant change in mood state score (WMD = 0.03; 95% CI:-0.80 to 0.87, P = 0.16). Moreover, no significant effect of blueberry intake was shown in attention task reaction time (WMD =-1.50 ms; 95% CI:-24.75 to-21.75, P = 0.9), per-centages of attention task accuracy (WMD = 0.85; 95% CI:-2.57 to 0.86, P = 0.3), one-back test accuracy (WMD = 0.03; 95% CI:-0.04 to 0.09, P = 0.4). Significant effect was indicated (WMD = 0.08; 95% CI: 0.02 to 0.13, P = 0.005) in two-back test accuracy. Conclusion: We found a significant effect of blueberry consumption on two-back test accuracy as a cognitive outcome. More high-quality clinical trials according to the challenges mentioned seem to in-dicate the use of blueberry as a supplement for cognitive and mood health efficiently. © 2023 Bentham Science Publishers.
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