The Effects of Hesperidin Supplementation or Orange Juice Consumption on Anthropometric Measures in Adults: A Meta-Analysis of Randomized Controlled Clinical Trials Publisher Pubmed



Djafari F¹ ; Shahavandi M¹ ; Amini MR² ; Sheikhhossein F³ ; Shahinfar H^{1, 5} ; Payandeh N¹ ; Jafari A¹ ; Djafarian K³ ; Clark CCT⁴ ; Shabbidar S¹
Source: Clinical Nutrition ESPEN Published:2021

Abstract

Background: The current evidence-base regarding the effect of hesperidin (a flavanone found in citrus fruits) on body composition is equivocal. Objective: We conducted a meta-analysis on the effect of orange juice and/or hesperidin supplementation on anthropometric measures in randomized controlled trials (RCTs). Materials and methods: A systematic search of PubMed and Scopus was performed up to February 2020. The overall estimates and their 95% confidence intervals (CIs) were calculated using a random-effects model. Results: Eleven eligible RCTs, with 512 individuals, were included in this study. The meta-analysis showed that orange juice and/or hesperidin had no significant effect on body weight [weighted mean difference (WMD) = −0.31 kg; 95% CI, −1.44 to 0.82, P = 0.592], body mass index [WMD = 0.11 kg/m2; 95% CI, −0.33 to 0.56, P = 0.617], fat mass [WMD = 0.14 kg; 95% CI, −0.95 to 1.22, P = 0.807], percentage body fat [WMD = −0.70%; 95% CI, −2.58 to 1.18, P = 0.463] and waist circumference [WMD = 0.07 cm; 95% CI, −1.16 to 1.30, P = 0.588]. Conclusion: The present study revealed that there is no significant beneficial effect of orange juice and/or hesperidin supplementation on anthropometric measures. The authors advocate that more high-quality clinical trials are needed to better discern the potential efficacy of orange juice and/or hesperidin. © 2021 European Society for Clinical Nutrition and Metabolism