Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications

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Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications Publisher Pubmed

Malek Khatabi A ; Rahimzadegan M ; Razavi M S ; Shabankareh A N T ; Sefat F ; Nosrati R

Source: Biomedicine and Pharmacotherapy Published:2026

Abstract

One major barrier inhibiting most pharmaceutical administrations' effectiveness is the cellular membrane's insufficient permeability. Cell-penetrating peptides (CPPs) are extensively identified as effective biological carriers that can pass through this natural barrier and transport the CPPs-conjugated therapeutic agents into cells. In this line, CPPs-assisted delivery systems have become one of the most popular methods for internalizing nanoparticles (NPs). Recently, CPPs-functionalized PLGA-derived nanocarriers have attracted exceptional attention because of their distinctive features that make them highly appealing for use in next-generation drug delivery systems (DDS). CPPs-conjugated PLGA NPs have demonstrated promise as therapeutic agents in a range of medical fields. This review article summarizes the current development of the CPPs/PLGA nanocarriers. After that, we explore their various challenges and optimization techniques. Finally, future prospects and challenges of CPPs/PLGA nanocarriers are mentioned concisely. © 2026 The Authors.

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Style	Citing Format
MLA	Malek Khatabi A, et al.. "Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications." Biomedicine and Pharmacotherapy, vol. 201, no. , 2026, pp. -.
APA	Malek Khatabi A, Rahimzadegan M, Razavi M S, Shabankareh A N T, Sefat F, Nosrati R (2026). Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications. Biomedicine and Pharmacotherapy, 201(), -.
Chicago	Malek Khatabi A, Rahimzadegan M, Razavi M S, Shabankareh A N T, Sefat F, Nosrati R. "Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications." Biomedicine and Pharmacotherapy 201, no. (2026): -.
Harvard	Malek Khatabi A et al. (2026) 'Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications', Biomedicine and Pharmacotherapy, 201(), pp. -.
Vancouver	Malek Khatabi A, Rahimzadegan M, Razavi M S, Shabankareh A N T, Sefat F, Nosrati R. Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications. Biomedicine and Pharmacotherapy. 2026;201():-.
BibTex	@article{ author = {Malek Khatabi A and Rahimzadegan M and Razavi M S and Shabankareh A N T and Sefat F and Nosrati R}, title = {Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications}, journal = {Biomedicine and Pharmacotherapy}, volume = {201}, number = {}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Malek Khatabi A AU - Rahimzadegan M AU - Razavi M S AU - Shabankareh A N T AU - Sefat F AU - Nosrati R TI - Cell-Penetrating Peptides (Cpps)-Engineered Plga Nanocarriers for Enhanced Drug Delivery: Uptake Mechanisms, Optimization Strategies, and Therapeutic Applications JO - Biomedicine and Pharmacotherapy VL - 201 IS - SP - EP - PY - 2026 ER -