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Therapeutic Effects of Anti-Diabetic Drugs on Traumatic Brain Injury Publisher Pubmed



Razavi SM1, 2 ; Arab ZN1, 2 ; Niknejad A1, 2 ; Hosseini Y1, 2 ; Fouladi A2, 3 ; Khales SD1, 2 ; Shahali M4 ; Momtaz S2, 5, 6 ; Butler AE7 ; Sukhorukov VN8, 9 ; Jamialahmadi T10 ; Abdolghaffari AH1, 2 ; Sahebkar A11, 12
Authors
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Authors Affiliations
  1. 1. Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
  2. 2. GI Pharmacology Interest Group (GPIG), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  3. 3. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
  6. 6. Department of Toxicology and Pharmacology, School of Pharmacy, and Toxicology and Diseases Group, Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Research Department, Royal College of Surgeons in Ireland Bahrain, Adliya, Bahrain
  8. 8. Institute of General Pathology and Pathophysiology, Moscow, Russian Federation
  9. 9. Institute of Experimental Cardiology Named after Academician V.N. Smirnov, Federal State Budgetary Institution National Medical Research Center of Cardiology Named after Academician E.I. Chazov, Moscow, Russian Federation
  10. 10. Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  11. 11. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran
  12. 12. Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2024


Abstract

Aims: In this narrative review, we have analyzed and synthesized current studies relating to the effects of anti-diabetic drugs on traumatic brain injury (TBI) complications. Methods: Eligible studies were collected from Scopus, Google Scholar, PubMed, and Cochrane Library for clinical, in-vivo, and in-vitro studies published on the impact of anti-diabetic drugs on TBI. Results: Traumatic brain injury (TBI) is a serious brain disease that is caused by any type of trauma. The pathophysiology of TBI is not yet fully understood, though physical injury and inflammatory events have been implicated in TBI progression. Several signaling pathways are known to play pivotal roles in TBI injuries, including Nuclear factor erythroid 2-related factor 2 (Nrf2), High mobility group box 1 protein/Nuclear factor kappa B (HMGB1/NF-κB), Adiponectin, Mammalian Target of Rapamycin (mTOR), Toll-Like Receptor (TLR), Wnt/β-catenin, Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT), Nod-like receptor protein3 (NLRP3) inflammasome, Phosphoglycerate kinase 1/Kelch-like ECH-associated protein 1 (PGK1/KEAP1)/Nrf2, and Mitogen-activated protein kinase (MAPK). Recent studies suggest that oral anti-diabetic drugs such as biguanides, thiazolidinediones (TZDs), sulfonylureas (SUs), sodium-glucose cotransporter-2 inhibitors (SGLT2is), dipeptidyl peptidase-4 inhibitors (DPPIs), meglitinides, and alpha-glucosidase inhibitors (AGIs) could have beneficial effects in the management of TBI complications. These drugs may downregulate the inflammatory pathways and induce antioxidant signaling pathways, thus alleviating complications of TBI. Conclusion: Based on this comprehensive literature review, antidiabetic medications might be considered in the TBI treatment protocol. However, evidence from clinical trials in patients with TBI is still warranted. © 2024 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC)
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