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Introduction on Neuroinflammation Publisher



Yazdanpanah N1, 2, 3 ; Rezaei N2, 3, 4
Authors
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Authors Affiliations
  1. 1. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Translational Neuroimmunology: Neuroinflammation: Volume 7 Published:2023


Abstract

Peripheral inflammation can provoke a neuroinflammatory response. Neuroinflammation is the body’s intrinsic response against trauma, infection, degenerative processes, and any type of insult. Previously, the blood-brain barrier was considered as an impermeable barrier that completely isolates the CNS from other tissues in the body. However, peripheral proinflammatory mediators can pass the BBB, while BBB is also a specialized endothelium capable of secreting and transferring the mediators and allowing the immune cells to enter the CNS. Different cellular and molecular components contribute to neuroinflammation. Neuroinflammation is sometimes considered as a double-edge sword, as acute episodes can be neuroprotective, whereas chronic events can be detrimental, resulting in synaptic damage, neuronal death, and worsening of many diseases. © 2023 Elsevier Inc. All rights reserved.
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Nima Rezaei (4)
Raika Jamali (1)