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Introduction on Cancer Immunology and Immunotherapy Publisher



Rezaei N1, 2, 3 ; Aalaeiandabili SH1, 4, 5 ; Amini N6, 7, 8 ; Delavari F9 ; Keshavarzfathi M10, 11 ; Kaufman HL12
Authors
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Authors Affiliations
  1. 1. Research Center for Immunodeficiencies, Children's Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  4. 4. Thoracic and Cardiovascular Surgery, Department of Surgery, College of Medicine, University of Florida, Gainesville, FL, United States
  5. 5. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Gainesville, FL, United States
  6. 6. Department of Surgery, Sinai Hospital, Baltimore, MD, United States
  7. 7. Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, United States
  8. 8. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Baltimore, MD, United States
  9. 9. Interactive Research Education and Training Association (IRETA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  10. 10. Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  11. 11. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  12. 12. Department of General Surgery and Immunology and Microbiology, Rush University Medical Center, Rush University Cancer Center, Chicago, IL, United States

Source: Cancer Immunology: A Translational Medicine Context# Second Edition Published:2020


Abstract

Cancer, a major public health threat affecting people at all ages, is characterized by uncontrolled cell growth and genetic instability. The immune system can recognize tumor cells and mediate antigen-specific tumor rejection under certain condition. The molecular and cellular basis of immune recognition and antitumor immunity is now better understood. In addition, it is now evident that tumors may mediate immunosuppression through various soluble and cellular mechanisms which protect established tumors from immune system recognition or rejection. These advances in understanding the role of the immune system in cancer have led to a variety of specific and nonspecific approaches designed to initiate or enhance antitumor immunity, which in turn result in significant therapeutic effects in a variety of cancers. Moreover, immunotherapy is being established as a major class of drugs for cancer therapy. This chapter will review the scope of the cancer problem, describe the basis of antitumor immunity, and introduce the concept of tumor immunotherapy. © Springer Nature Switzerland AG 2020.
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