Age-Related Macular Degeneration in an Iranian Population



Hashemi H^{1, 2} ; Ghafari E¹ ; Khabazkhoob M¹ ; Noori J² ; Taheri A² ; Eshghabadi A¹ ; Khodabandeh A¹ ; Emamian MH³ ; Shariati M⁴ ; Fotouhi A⁵ Show Affiliations
Source: Iranian Journal of Ophthalmology Published:2015

Abstract

Purpose: To determine the prevalence and determinants of age-related macular degeneration (AMD) in a 40-64 year old Iranian population Methods: In a cross-sectional study, 6,311 people were randomly selected from Shahroud. For all participants, visual acuity, refraction, slit-lamp examination and fundus photography were conducted under pupil dilation. Results: Results of this study are based on analysis of 4,387 high quality photographs. The prevalence of AMD in this study was 4.7% (95% confidence interval (CI): 4.1-5.4). Multiple logistic regression analysis revealed that only older age [odds ratio (OR)=1.07] and hyperopia (OR=1.12) significantly correlated with AMD. Associations with biometric components and spherical equivalent were studied in another model and older age (OR=1.08), male sex (OR=1.54), and ocular axial length (OR=0.66) significantly correlated with AMD. Conclusion: AMD prevalence in this population was lower compared to Western countries and higher in comparison to East Asian countries. In agreement with other studies, age strongly correlated with AMD. Regarding the correlation between AMD and ocular axial length; the incidence is more likely to occur in people with short axial lengths. © 2014 by the Iranian Society of Ophthalmology.