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Clinical Improvement of Diabetes Mellitus Type 1 by Β-D-Mannuronic Acid (M2000) in a Breast Cancer Patient - As a Case Report Publisher



Kashefi S1 ; Omranipour R2, 3 ; Mahmoodzadeh H3 ; Ahmadi H2 ; Mirshafiey A1
Authors
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Authors Affiliations
  1. 1. Department of Immunology, School of Public Health, Tehran University of Medical Science, Tehran, Iran
  2. 2. Breast Cancer Research Center (BDRC), Tehran University of Medical Science, Tehran, Iran
  3. 3. Department of Surgical Oncology, Tehran University of Medical Science, Tehran, Iran

Source: Clinical Diabetology Published:2019


Abstract

A 56 years old female with breast cancer (BC) and poor controlled diabetes mellitus type 1 (DM1) which has registered in a clinical trial for assessment of therapeutic efficacy of β-D-mannuronic acid (M2000) on pre-surgical BC patients is described in this case report. After receiving M2000, the patient was followed for 9 weeks. During this period, cancer mass details, fasting blood glucose (FBG) levels, 2-hour post-prandial blood glucose (2HPP), blood uric acid (BUA) level and urine analysis (UA) were continuously controlled. After 9 weeks of treatment with M2000, her FBG, BUA and UA decreased significantly. This finding was exactly in accordance with our published experimental data about the anti-diabetic effect of M2000 in an animal model. Therefore, it might be concluded that M2000 is probably able to improve DM1 by reducing FBG level, BUA level, glycosuria, ketonuria and proteinuria. © 2019 Via Medica. All rights reserved.
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