Correlation of Clinical Signs and Symptoms of Behcet’S Disease With Mean Platelet Volume (Mpv) and Red Cell Distribution Width (Rdw) Publisher Pubmed



Masoumi M¹ ; Shadmanfar S² ; Davatchi F³ ; Shahram F³ ; Akhlagi M³ ; Faezi T³ ; Kavosi H³ ; Moradi S² ; Balasi J⁴ Show Affiliations
Source: Orphanet Journal of Rare Diseases Published:2020

Abstract

Background: A strong correlation was previously found between mean platelet volume (MPV), red blood cell distribution width (RDW), and the severity of signs and symptoms in patients suffering from inflammatory and autoimmune diseases. The current study evaluated these correlations in patients with Behcet’s disease (BD) as well the relationship between MPV and RDW and disease activity score on the Iranian Behcet’s Disease Dynamic Activity Measurement (IBDDAM). Methods: This cross-sectional study included 319 patients with BD for whom demographic and epidemiological data, IBDDAM scores, and duration of illness was recorded. Blood samples were then obtained and the relationships between their disease status and manifestations and their laboratory parameters were evaluated with statistical models to find possible correlations. Results: Our analysis showed a significantly higher RDW in patients with BD who had ocular manifestations (p < 0.001) and oral aphthae (p = 0.004). Patients with active BD had higher RDW (p < 0.001) and MPV (p < 0.001) in comparison to those with currently inactive BD. Similarly, patients who had any type of ocular manifestation had higher RDW (p < 0.001) and MPV (p < 0.001). Regression analyses identified a statistically significant model for the effect of RDW and MPV in predicting active BD status (p < 0.001), as well as its significant relationship with active ocular manifestations (p < 0.001). Conclusion: BD was found to be associated with an increase in MPV and RDW, particularly during active phases. RDW and MPV were also found to have predictive value for screening to detect BD activity and its ocular complications. © 2020, The Author(s).