Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A

Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A Publisher

Jamal A¹ ; Vosoogh S² ; Tabatabaei RS³ ; Salamat F⁴

Source: Shiraz E Medical Journal Published:2022

Abstract

Background: Patients with a low level of pregnancy-associated plasma protein-A (PAPP-A) experience more placental disorders in the second trimester. Objectives: We aimed to assess UtA-Doppler and placental size to predict adverse pregnancy outcomes in a woman with placental insufficiency and low PAPP-A. Methods: Following a cross-sectional design, 83 singleton pregnant women with normal chromosomes and PAPP-A ≤ 0.5 were examined at 11-13 + 6 weeks of gestation. All participants with PAPP-A ≤ 0.5 were tested in the Nilo laboratory of Tehran from 2018 to 2019. The placental size and Doppler uterine artery were assessed at 18-20 weeks. Three cases were excluded due to abortion and aneuploidy. All participants were assigned to placenta lengths of < 10 cm and > 10 cm. All comparisons between two groups were assayed by the independent t-test, Mann-Whitney U test, χ2-test or Fisher exact test, and Logistic regression model. Results: Of 80 women, 48 (60%) had placenta length of < 10 cm and 32(40%) had placenta length of > 10 cm. Fourteen (17.5%) were preterm (< 32 weeks), and 36(45%) were IUGR. According to the logistic regression model, in participants with a placenta length of < 10 cm, the risk of IUGR was higher by 9-time than those with placenta length of > 10 cm (OR = 9, CI95% = 3.20-25.29). Also, the risk of preterm labor was 3.47 fold higher in the group with placenta length of < 10 cm, OR: 3.47;(CI95% = 1.27-9.44). Sensitivity of placenta length of < 10 cm for predicting IUGR was 75% (CI95% = 56.60-88.54). Conclusions: Placental length measurement in the second trimester can help predict adverse pregnancy outcomes in pregnant women with low PAPP-A. Placenta evaluation can assist in planning future pregnancy care to detect the pathology of fetal growth restriction. © 2022, Author(s).

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Style	Citing Format
MLA	Jamal A, et al.. "Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A." Shiraz E Medical Journal, vol. 23, no. 7, 2022, pp. -.
APA	Jamal A, Vosoogh S, Tabatabaei RS, Salamat F (2022). Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A. Shiraz E Medical Journal, 23(7), -.
Chicago	Jamal A, Vosoogh S, Tabatabaei RS, Salamat F. "Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A." Shiraz E Medical Journal 23, no. 7 (2022): -.
Harvard	Jamal A et al. (2022) 'Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A', Shiraz E Medical Journal, 23(7), pp. -.
Vancouver	Jamal A, Vosoogh S, Tabatabaei RS, Salamat F. Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A. Shiraz E Medical Journal. 2022;23(7):-.
BibTex	@article{ author = {Jamal A and Vosoogh S and Tabatabaei RS and Salamat F}, title = {Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A}, journal = {Shiraz E Medical Journal}, volume = {23}, number = {7}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Jamal A AU - Vosoogh S AU - Tabatabaei RS AU - Salamat F TI - Placental Size and Uterine Artery Doppler for Prediction of Adverse Pregnancy Outcomes in Women With Low Pregnancy-Associated Plasma Protein-A JO - Shiraz E Medical Journal VL - 23 IS - 7 SP - EP - PY - 2022 ER -

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