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Placental Pathological Findings and Their Association With Maternal and Fetal Clinical Outcomes: A Cross-Sectional Study Publisher



Sarmadi S1 ; Mirzaian E2 ; Nili F3 ; Khalafrezaei F4
Authors
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Authors Affiliations
  1. 1. Department of Pathology, Yas Women Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pathology, Kosar Hospital, Semnan University of Medical Sciences, Semnan, Iran

Source: International Journal of Reproductive BioMedicine Published:2024


Abstract

Background: Placental pathological changes can occur in both normal and high-risk pregnancies, leading to adverse maternal and neonatal outcomes. Objective: This study aimed to investigate the relationship between placental histopathological findings and maternal and fetal clinical outcomes, as well as to determine if there is an association between maternal comorbidities and placental pathologies. Materials and Methods: In this study, 250 placenta samples were evaluated. The slides and paraffin blocks were retrieved from the archive of the pathology department of Shariati and Yas hospitals, Tehran, Iran. The placental histopathological findings were analyzed in relation to maternal and fetal clinical data. Results: The average age of pregnant women was 31.84 yr. The average gestational age at birth was 28 wk. The most prevalent pathological finding was maternal vascular malperfusion, observed in 59.6% of cases. The presence of nucleated red blood cells (NRBC) in umbilical cord blood vessels was observed in 16.4% of cases. Fetal vascular malperfusion was significantly associated with intrauterine fetal demise. Maternal inflammatory response was associated with premature rupture of membranes. Maternal vascular malperfusion and the presence of NRBC in umbilical cord blood vessels was significantly associated with pre-eclampsia and preterm labor. Furthermore, a history of maternal malignancy was associated with placental infarction and the presence of NRBC in umbilical cord blood vessels. Conclusion: The findings of this study underscore the importance of evaluating placental histopathological findings in relation to maternal and fetal clinical outcomes. Therefore, understanding these placental pathological changes will be crucial in predicting and preventing complications in subsequent pregnancies. © 2024, Research and Clinical Center for Infertitlity. All rights reserved.