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The Core Needle and Surgical Biopsy Concordance to Detect Estrogen, Progesterone, and Her-2 Receptors in Breast Cancer: A Comparative Study



Ensani F1 ; Omranipour R2 ; Jahanzad I3 ; Jafari A1 ; Nafarzadeh S4 ; Aminishakib P5
Authors
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Authors Affiliations
  1. 1. Dept. of Pathology, Cancer Institute Hospital, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Surgical Oncology Center Institute Hospital, Tehran University of Medical Science, Tehran, Iran
  3. 3. Dept. of Immunohistochemistry, Cancer Institute, Tehran University of Medical Science, Tehran, Iran
  4. 4. Dept. of Oral and Maxillofacial Pathology, Babol University of Medical Sciences, Tehran, Iran
  5. 5. Dept. of Oral and Maxillofacial Pathology, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Pathology Published:2017

Abstract

Background &Objectives: Evaluation of estrogen receptor (ER), progesterone receptor (PR), and (human epidermal growth factor receptor-2) Her-2 on core needle biopsies (CNBs) is increasingly in use to diagnosis early breast cancer, but its concordance with surgical excision (SE) is not well documented. Methods: The study included 100 formalin fixed, paraffin-embedded specimens of invasive breast carcinoma archived in Pathology Department of Cancer Institute, Tehran, Iran, from 2011 to 2014. Immunohistochemistry was applied to detect ER, PR, and Her-2. Results: The current study findings indicated a significant correlation of 90% between CNB and SE specimens for ER expression. The correlation between CNB and SE specimens was estimated as 81% and 97.3% for PR and Her-2, respectively. Discussion: CNB can be performed confidently to determine ER and Her-2. For PR, results obtained from CNB should be considered. © 2017, IRANIAN JOURNAL OF PATHOLOGY.