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Association Study of Cd226 and Cd247 Genes Single Nucleotide Polymorphisms in Iranian Patients With Systemic Sclerosis Pubmed



Abbasi F1 ; Mansouri R1 ; Gharibdoost F2 ; Aslani S2 ; Mostafaei S2 ; Kavosi H2 ; Poursani S2 ; Sobhani S2 ; Mahmoudi M2
Authors
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Authors Affiliations
  1. 1. Immunology Department, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  2. 2. Rheumatology Research Center, Tehran University of Medical Sciences, PO.BOX: 1411713137, Tehran, Iran

Source: Iranian Journal of Allergy# Asthma and Immunology Published:2017


Abstract

CD247 and CD226 play important roles in signaling of lymphocytes. Single nucleotide polymorphisms (SNPs) of genes encoding CD247 and CD226 have been associated with the risk of several autoimmune disorders. This study aimed to evaluate the possible association between CD226 and CD247 genes SNPs and risk of systemic sclerosis (SSc) in Iranian population. Study participants were 455 SSc patients and 455 age, sex, and ethnic -matched healthy individuals. Genotyping of rs2056626 and rs763361 at CD247 and CD226 genes, respectively, was carried out using TaqMan MGB-based allelic discrimination real-time PCR. Neither alleles nor genotypes of both SNPs showed significant association with the risk of SSc. Furthermore, association analysis of the genotypes with clinical manifestations of the disease revealed that rs763361 variants were associated with the forced vital capacity (FVC) in SSc patients. Our results suggest that genetic variants of CD226 and CD247 genes may not be a contributing factor in pathogenesis of SSc in Iranian population. © Autumn 2017, Iran J Allergy Asthma Immunol. All rights reserved.
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