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Sodium Selenite and Se-Enriched Yeast Supplementation in Atherosclerotic Patients: Effects on the Expression of Pyroptosis-Related Genes and Oxidative Stress Status Publisher Pubmed



Roshanravan N1 ; Koche Ghazi MK2 ; Ghaffari S1 ; Naemi M2 ; Alamdari NM3 ; Shabestari AN4 ; Mosharkesh E5 ; Soleimanzadeh H6 ; Sadeghi MT1 ; Alipour S7 ; Bastani S8 ; Tarighatesfanjani A2
Authors
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Authors Affiliations
  1. 1. Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  2. 2. Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Geriatric Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran
  6. 6. Department of Applied Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
  7. 7. Department of Clinical Biochemistry and Applied Cell Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  8. 8. Stem Cell And Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

Source: Nutrition# Metabolism and Cardiovascular Diseases Published:2022


Abstract

Background and aims: Atherosclerosis as a chronic inflammatory disorder of the arterial wall is the main leading cause of the cardiovascular disease (CVD). Caspase-dependent pyroptosis plays a pivotal role in the pathogenesis of CVD. Selenium (Se) is an important component of the antioxidant defense and plays a crucial role in cardiovascular health. This study aimed to investigate the effects of daily consumption of sodium selenite and Se-enriched yeast on the expression of pyroptosis-related genes, and biomarkers of oxidative stress in patients with atherosclerosis. Methods and results: In this randomized, double-blinded, placebo-controlled clinical trial, 60 patients with atherosclerosis were recruited. Participants received 200 μg/day of sodium selenite, Se-enriched yeast, or placebo for 8 following weeks. The pyroptosis-related genes’ mRNA expression in peripheral blood mononuclear cells (PBMCs) was assessed before and after the intervention. Also, the levels of superoxide dismutase (SOD), malondialdehyde (MDA), nitric oxide (NO), and glutathione peroxidases (GPX) were measured at baseline and following the intervention. Following sodium selenite and Se-enriched yeast supplementation, the relative expression levels of TLR4, ASC, NLRP3, and NF-κB1 were significantly downregulated (p < 0.05). Furthermore, the changes in GPX were significantly increased after selenite and yeast supplementation (p < 0.05). Also, selenite and yeast consumption caused a statistically significant decrease in the change of MDA level (p < 0.05). Conclusion: In summary, these findings showed that Se supplementation may reduce inflammation through down-regulation of some pro-inflammatory genes, improving antioxidant defenses in atherosclerosis patients. Further research is required to come to a definite conclusion of selenium supplementation on the CVD risk. This study was registered on the Iranian Registry of Clinical Trials website (identifier: RCT20110123005670N28; https://www.irct.ir/). © 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
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