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The Effects of Opium Tincture and Methadone on the Cognitive Function of Patients With Opioid Use Disorder Publisher



Wong JSH1 ; Nikoo M1 ; Kianpoor K1 ; Gholami A2 ; Jazani M3 ; Mohammadian F4 ; Lafooraki NY5 ; Jang KL6 ; Schutz CG7 ; Akhondzadeh S8 ; Krausz MR1
Authors
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Authors Affiliations
  1. 1. Addictions and Concurrent Disorders Research Group, Institute of Mental Health, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
  2. 2. Kian Methadone Maintenance Treatment Clinic, Private Practice and Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran
  3. 3. Sales, Marketing, Export, and Medical Department, Darou Pakhsh Pharmaceutical Mfg. Co., Tehran, Iran
  4. 4. Darou Pakhsh Pharmaceutical Mfg Co., Tehran, Iran
  5. 5. Islamic Azad University, Science and Research Branch, Mazandaran, Iran
  6. 6. Institute of Mental Health, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
  7. 7. Behavioral Reward Affect + Impulsivity Neuroscience Lab, Institute of Mental Health, Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
  8. 8. Psychiatric Research Center, Roozbeh Hospital, Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran

Source: Personality and Individual Differences Published:2021


Abstract

Individuals vary in their cognitive function, which is influenced by genetics and environmental factors such as opioids. Over 16 million people worldwide are affected by opioid use disorder (OUD), and opioid agonist treatment (OAT) is the most effective treatment for OUD. Evaluating cognitive function in patients with OUD receiving OAT is crucial as cognitive impairments affect everyday functioning and treatment outcomes. Studies on the cognitive effects of two forms of OAT, methadone and opium tincture (OT), have been limited and inconsistent. We thereby examined the cognitive function of patients with OUD treated with OT or methadone. In a randomized controlled trial, participants with OUD were randomized to OT or methadone. Cognition was measured by the Montreal Cognitive Assessment (MoCA). Participants completed the MoCA at baseline, week 4, 8, and 12. The cognitive function of participants improved significantly. There was improvement from OAT initiation to week 4, but this improvement plateaued from week 4 to 12. There were no significant differences in cognitive function between participants receiving OT and methadone. Our findings support the role of both OT and methadone in improving the cognitive function of patients with OUD. This may help enhance the overall rehabilitation and social reintegration of patients. © 2020 Elsevier Ltd
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