Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Possible Involvement of Atp-Sensitive Potassium Channels in the Antidepressant-Like Effect of Baclofen in Mouse Forced Swimming Test Publisher Pubmed



Nazari SK1 ; Nikoui V2 ; Ostadhadi S3, 4, 5 ; Chegini ZH1 ; Oryan S1 ; Bakhtiarian A3, 5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Faculty of Biology Sciences, Kharazmi University, Tehran, Iran
  2. 2. Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Pharmacological Reports Published:2016


Abstract

Background Previous study confirmed that the acute treatment with baclofen by inhibition of the L-arginine-nitric oxide (NO) pathway diminished the immobility behavior in the forced swimming test (FST) of mice. Considering the involvement of NO in adenosine triphosphate (ATP)-sensitive potassium channels (KATP), in the present study we investigated the involvement of KATP channels in antidepressant-like effect of baclofen in the FST. Methods After assessment of locomotor behavior in the open-field test (OFT), FST was applied for evaluation of the antidepressant-like activity of baclofen in mice. Baclofen at different doses (0.1, 0.3, and 1 mg/kg) and fluoxetine (20 mg/kg) were administrated by intraperitoneal (ip) route, 30 min before the FST or OFT. To clarify the probable involvement of KATP channels, after determination of sub-effective doses of glibenclamide as a KATP channel blocker and cromakalim, as an opener of these channels, they were co-administrated with the sub-effective and effective doses of baclofen, respectively. Results Baclofen at dose 1 mg/kg significantly decreased the immobility behavior of mice similar to fluoxetine (20 mg/kg). Co-administration of gelibenclamide sub-effective dose (1 mg/kg) with baclofen (0.1 mg/kg) showed a synergistic antidepressant-like effect in the FST. Also, sub-effective dose of cromakalim (0.1 mg/kg) inhibited the antidepressant-like effect of baclofen (1 mg/kg) in the FST. All aforementioned treatments had not any impact on the locomotor movement of mice in OFT. Conclusions Our study for the first time revealed that antidepressant-like effect of baclofen on mice is KATP-dependent, and baclofen seems that exert this effect by blocking the KATP channels. © 2016
Related Docs
View other Related Docs
1. Possible Involvement of Atp-Sensitive Potassium Channels in the Antidepressant-Like Effects of Gabapentin in Mouse Forced Swimming Test, Canadian Journal of Physiology and Pharmacology (2017)
2. Evaluation of the Pharmacological Involvement of Atp-Sensitive Potassium (Katp) Channels in the Antidepressant-Like Effects of Topiramate on Mice, Naunyn-Schmiedeberg's Archives of Pharmacology (2019)
3. The Effect of Nitrazepam on Depression and Curiosity in Behavioral Tests in Mice: The Role of Potassium Channels, European Journal of Pharmacology (2016)
4. The Role of Nmda Receptor and Nitric Oxide/Cyclic Guanosine Monophosphate Pathway in the Antidepressant-Like Effect of Dextromethorphan in Mice Forced Swimming Test and Tail Suspension Test, Biomedicine and Pharmacotherapy (2017)
5. Nitric Oxide Involvement in Additive Antidepressant-Like Effect of Agmatine and Lithium in Mice Forced Swim Test, Psychiatry Research (2018)
6. Agmatine Enhances the Antidepressant-Like Effect of Lithium in Mouse Forced Swimming Test Through Nmda Pathway, Biomedicine and Pharmacotherapy (2017)
7. Lithium Attenuated the Behavioral Despair Induced by Acute Neurogenic Stress Through Blockade of Opioid Receptors in Mice, Biomedicine and Pharmacotherapy (2016)
8. Pharmacological Evidence for the Involvement of the Nmda Receptor and Nitric Oxide Pathway in the Antidepressant-Like Effect of Lamotrigine in the Mouse Forced Swimming Test, Biomedicine and Pharmacotherapy (2016)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Dehpour (43)
Seyedeh Elahe Mousavi (2)
Other Related Docs
9. Antidepressant-Like Effect of Ethanol in Mice Forced Swimming Test Is Mediated Via Inhibition of Nmda/Nitric Oxide/Cgmp Signaling Pathway, Alcohol (2021)
10. Antidepressant Effect of Pramipexole in Mice Forced Swimming Test: A Cross Talk Between Dopamine Receptor and Nmda/Nitric Oxide/Cgmp Pathway, Biomedicine and Pharmacotherapy (2016)
11. Pharmacological Profile for the Contribution of No/Cgmp Pathway on Chlorpheniramine Antidepressant-Like Effect in Mice Forced Swim Test, Acta Medica Iranica (2018)
12. Involvement of Nmda Receptors in the Antidepressant-Like Effect of Tramadol in the Mouse Forced Swimming Test, Brain Research Bulletin (2017)
13. The Involvement of Nmda Receptor/No/Cgmp Pathway in the Antidepressant Like Effects of Baclofen in Mouse Force Swimming Test, Neuroscience Letters (2016)
14. Involvement of Nmda Receptors and L-Arginine/Nitric Oxide/Cyclic Guanosine Monophosphate Pathway in the Antidepressant-Like Effects of Topiramate in Mice Forced Swimming Test, Brain Research Bulletin (2016)
15. The Role of Nitric Oxide–Cgmp Pathway in Selegiline Antidepressant-Like Effect in the Mice Forced Swim Test, Pharmacological Reports (2018)
16. Involvement of No/Cgmp Pathway in the Antidepressant-Like Effect of Gabapentin in Mouse Forced Swimming Test, Naunyn-Schmiedeberg's Archives of Pharmacology (2016)
17. Involvement of Nitric Oxide-Cyclic Guanosine Monophosphate Pathway in the Antidepressant-Like Effect of Tropisetron and Ondansetron in Mice Forced Swimming Test and Tail Suspension Test, European Journal of Pharmacology (2016)
18. Involvement of N-Methyl-D-Aspartate Receptors in the Antidepressant-Like Effect of 5-Hydroxytryptamine 3 Antagonists in Mouse Forced Swimming Test and Tail Suspension Test, Pharmacology Biochemistry and Behavior (2016)
19. Neurobiology and Consequences of Social Isolation Stress in Animal Model—A Comprehensive Review, Biomedicine and Pharmacotherapy (2018)
20. Fluoxetine Reverses the Behavioral Despair Induced by Neurogenic Stress in Mice: Role of N-Methyl-D-Aspartate and Opioid Receptors, Canadian Journal of Physiology and Pharmacology (2016)
21. Activation of Cannabinoid Receptors Elicits Antidepressant-Like Effects in a Mouse Model of Social Isolation Stress, Brain Research Bulletin (2017)
22. Involvement of Opioid System in Behavioral Despair Induced by Social Isolation Stress in Mice, Biomedicine and Pharmacotherapy (2019)
23. Anticonvulsant Effect of Dextrometrophan on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide and N-Methyl-D-Aspartate Receptors, Epilepsy and Behavior (2016)
24. Melatonin Attenuated the Behavioral Despair Induced by Acute Neurogenic Stress Through Blockade of N-Methyl D-Aspartate Receptors in Mice, Heliyon (2021)
25. The Role of Ca3 Gabab Receptors on Anxiolytic-Like Behaviors and Avoidance Memory Deficit Induced by D-Ap5 With Respect to Ca2 + Ions, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2017)
26. Involvement of Opioid System in Antidepressant-Like Effect of the Cannabinoid Cb1 Receptor Inverse Agonist Am-251 After Physical Stress in Mice, Clinical and Experimental Pharmacology and Physiology (2016)
27. Attenuation of Oxidative and Nitrosative Stress in Cortical Area Associates With Antidepressant-Like Effects of Tropisetron in Male Mice Following Social Isolation Stress, Brain Research Bulletin (2016)
28. Involvement of No/Nmda-R Pathway in the Behavioral Despair Induced by Amphetamine Withdrawal, Brain Research Bulletin (2018)
29. The Role of Opioid and Nitrergic Systems in Dual Modulation of Seizure Susceptibility, Advancements in Life Sciences (2020)
30. Evidence for the Involvement of Nmda Receptors in the Antidepressant-Like Effect of Nicotine in Mouse Forced Swimming and Tail Suspension Tests, Psychopharmacology (2015)
31. Evidence for the Involvement of Nitric Oxide in Cholestasis-Induced Itch Associated Response in Mice, Biomedicine and Pharmacotherapy (2016)
32. Elevated Level of Nitric Oxide Mediates the Anti-Depressant Effect of Rubidium Chloride in Mice, European Journal of Pharmacology (2015)
33. Minocycline Attenuates Depressive-Like Behaviour Induced by Rat Model of Testicular Torsion: Involvement of Nitric Oxide Pathway, Basic and Clinical Pharmacology and Toxicology (2016)
34. Co-Administration of the Low Dose of Orexin and Nitrergic Antagonists Induces an Antidepressant-Like Effect in Mice, Biomedicine and Pharmacotherapy (2019)
35. The Potential Role of Very Small Embryonic-Like Stem Cells in the Neuroinflammation Induced by Social Isolation Stress: Introduction of a New Paradigm, Brain Research Bulletin (2020)
36. Development of Resistance to Serotonin-Induced Itch in Bile Duct Ligated Mice, Clinical and Experimental Pharmacology and Physiology (2017)
37. Possible Involvement of Nitric Oxide in Antidepressant-Like Effect of Silymarin in Male Mice, Pharmaceutical Biology (2015)
38. The Effect of Bla Gabab Receptors in Anxiolytic-Like Effect and Aversive Memory Deficit Induced by Acpa, Tehran University Medical Journal (2016)
39. Behavioral Despair Associated With a Mouse Model of Crohn's Disease: Role of Nitric Oxide Pathway, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2016)
40. Effects of Short Term and Long Term Extremely Low Frequency Magnetic Field on Depressive Disorder in Mice: Involvement of Nitric Oxide Pathway, Life Sciences (2016)
41. Pharmacological Evidence for the Involvement of Adenosine Triphosphate Sensitive Potassium Channels in Chloroquine-Induced Itch in Mice, Pharmacological Reports (2017)
42. Ketamine-Induced Antidepressant Like Effects in Mice: A Possible Involvement of Cannabinoid System, Biomedicine and Pharmacotherapy (2019)
43. Lithium Attenuated the Depressant and Anxiogenic Effect of Juvenile Social Stress Through Mitigating the Negative Impact of Interlukin-1Β and Nitric Oxide on Hypothalamic-Pituitary-Adrenal Axis Function, Neuroscience (2016)
44. Anticonvulsant Effect of Minocycline on Pentylenetetrazole-Induced Seizure in Mice: Involvement of Nitric Oxide and N-Methyl-D-Aspartate Receptor, Canadian Journal of Physiology and Pharmacology (2018)
45. Saha Improves Depressive Symptoms, Cognitive Impairment and Oxidative Stress: Rise of a New Antidepressant Class, Neurochemical Research (2021)
46. Streptozotocin Induced Oxidative Stress, Innate Immune System Responses and Behavioral Abnormalities in Male Mice, Neuroscience (2017)
47. Lithium Attenuates the Proconvulsant Effect of Adolescent Social Isolation Stress Via Involvement of the Nitrergic System, Epilepsy and Behavior (2016)
48. Licofelone Attenuates Lps-Induced Depressive-Like Behavior in Mice: A Possible Role for Nitric Oxide, Journal of Pharmacy and Pharmaceutical Sciences (2019)
49. Involvement of D1 and D2 Dopamine Receptors in the Antidepressant-Like Effects of Selegiline in Maternal Separation Model of Mouse, Physiology and Behavior (2016)
50. Glatiramer Acetate Attenuates Depressive/Anxiety-Like Behaviors and Cognitive Deficits Induced by Post-Weaning Social Isolation in Male Mice, Psychopharmacology (2021)