Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis

Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis Publisher Pubmed

Ebrahimiadib N^{1, 2} ; Kianzad Z¹ ; Zarei M¹ ; Davoudi S³ ; Riaziesfahani H¹ ; Bazvand F¹ ; Mahdizad Z¹ ; Modjtahedi BS^{4, 5, 6}

Show Affiliations

1. Ophthalmology Department, Tehran University of Medical Sciences, Tehran, Iran
2. Ocular Immunology and Uveitis Foundation, Waltham, MA, United States
3. Department of Ophthalmology, Boston University School of Medicine, Boston, MA, United States
4. Department of Ophthalmology, Southern California Permanent Medical Group, Baldwin Park, CA, United States
5. Eye Monitoring Center, Kaiser Permanent Southern California, Baldwin Park, CA, United States
6. Department of Research and Evaluation, Southern California Permanente Medical Group, Pasadena, CA, United States

Source: Scientific Reports Published:2022

Abstract

To evaluate the relationship between non-cystic thickening of the macula on optical coherence tomography (OCT) and retinal vascular leakage on fluorescein angiogram (FA) in patients with uveitis. A cross-sectional study of patients seen in the uveitis clinic. Patients with any degree of inflammatory cells in the anterior vitreous were included, provided that no macular cyst or subretinal fluid or macular atrophy was observed in OCT. The correlation between OCT features and best corrected visual acuity (BCVA), the degree of inflammation, and FA findings were examined. The severity of vascular leakage in FA was graded for optic nerve, macula and posterior and peripheral leakage. We used generalized estimation equation to assess the associations between macular thickness and volume with angiographic scores. A total of 43 patients (100 exam data) met inclusion criteria. There was a significant relationship between OCT parameters (central macular thickness, 3 mm and 6 mm perifoveal macular thickness as well as total and central macular volume) with angiographic scores (macular, optic disc, posterior and peripheral vascular leakage score) (all P values < 0.0001). The correlation between the 6 mm perifoveal thickness and peripheral vascular leakage score (R = 0.76; P < 0.001) was stronger than the correlation of CMT with this angiographic score (R = 0.69; P < 0.001). Non-cystic thickening of the macula on OCT, especially in perifoveal area, is a reliable predictor of the presence of retinal vascular leakage in patients with uveitis. © 2022, The Author(s).

Style	Citing Format
MLA	Ebrahimiadib N, et al.. "Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis." Scientific Reports, vol. 12, no. 1, 2022, pp. -.
APA	Ebrahimiadib N, Kianzad Z, Zarei M, Davoudi S, Riaziesfahani H, Bazvand F, Mahdizad Z, Modjtahedi BS (2022). Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis. Scientific Reports, 12(1), -.
Chicago	Ebrahimiadib N, Kianzad Z, Zarei M, Davoudi S, Riaziesfahani H, Bazvand F, Mahdizad Z, Modjtahedi BS. "Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis." Scientific Reports 12, no. 1 (2022): -.
Harvard	Ebrahimiadib N et al. (2022) 'Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis', Scientific Reports, 12(1), pp. -.
Vancouver	Ebrahimiadib N, Kianzad Z, Zarei M, Davoudi S, Riaziesfahani H, Bazvand F, et al.. Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis. Scientific Reports. 2022;12(1):-.
BibTex	@article{ author = {Ebrahimiadib N and Kianzad Z and Zarei M and Davoudi S and Riaziesfahani H and Bazvand F and Mahdizad Z and Modjtahedi BS}, title = {Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis}, journal = {Scientific Reports}, volume = {12}, number = {1}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Ebrahimiadib N AU - Kianzad Z AU - Zarei M AU - Davoudi S AU - Riaziesfahani H AU - Bazvand F AU - Mahdizad Z AU - Modjtahedi BS TI - Non-Cystic Macular Thickening on Optical Coherence Tomography As an Alternative to Fluorescein Angiography for Predicting Retinal Vascular Leakage in Early Stages of Uveitis JO - Scientific Reports VL - 12 IS - 1 SP - EP - PY - 2022 ER -

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