Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Five-Year Changes in Macular Thickness in the Elderly Population: A Cohort Study Publisher Pubmed



Hashemi H1 ; Khabazkhoob M2 ; Heydarian S3 ; Emamian MH4 ; Fotouhi A5
Authors
Show Affiliations
Authors Affiliations
  1. 1. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran
  2. 2. Department of Basic Sciences, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of rehabilitation science, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Ophthalmic Epidemiology Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
  5. 5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Clinical and Experimental Ophthalmology Published:2024


Abstract

Background: The aim of this study is to determine the 5-year changes in macular thickness and related factors. Methods: Data were from the second (2014) and third (2019) phases of the Shahroud Eye Cohort Study. Examinations included measurement of uncorrected and best-corrected visual acuity, non-cycloplegic autorefraction, slit-lamp biomicroscopy, and funduscopy. Participants underwent Cirrus HD-OCT 4000 (Carl Zeiss Meditec, Dublin, CA). imaging. Results: The 5-year changes (95% confidence interval) of central and overall macular thicknesses were − 3.48 ± 8.16 μ (−3.92, −3.03) and − 0.79 ± 4.06 μ (−1.03, −0.54), respectively. The median and IQR of 5-year changes in the central subfield thickness were −3 and 10, although they were 0 and 5 in the overall macular thickness, respectively. Multiple regression model showed the central macular thickness (CMT) decreased with a U-shape pattern with increasing age. The 5-year changes in CMT were significantly lower in females compared to males β = −1.55; (−2.78, −0.32) and in smokers compared to non-smokers β = −1.92; (−3.55, −0.28). Moreover, higher body mass index β = −0.12; (−0.22, −0.02) and CMT at baseline β = −0.08; (−0.10, −0.06) were significantly associated with lower CMT changes. The average 5-year changes in overall macular thickness showed a non-linear decrease with age and was significantly higher in females β = 0.93; (0.4, 1.43). These changes were directly related to the anterior chamber depth β = 0.87; (0.10, 1.64) in the baseline. Conclusions: The macular thickness decreased slightly after 5 years; however, this change is not clinically significant. Demographic factors such as age and sex and refractive errors were significantly related to macular thickness changes. © 2024 Royal Australian and New Zealand College of Ophthalmologists.
Related Docs
1. The Distribution of Macular Thickness and Its Determinants in a Healthy Population, Ophthalmic Epidemiology (2017)
2. Macular Thickness by Using Spectral Domain Optical Coherence Tomography in Children and Adolescents, Retina (2022)
3. Optical Coherence Tomography Characteristics of Macular Edema and Hard Exudates and Their Association With Lipid Serum Levels in Type 2 Diabetes, Retina (2016)
Experts (# of related papers)
Akbar Fotouhi (2)