Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Resistance of Mycobacterium Tuberculosis Strains to Rifampicin: A Systematic Review and Meta-Analysis Publisher



Feyisa SG1, 2, 3 ; Abdurahman AA4 ; Jimma W5, 6 ; Chaka EE7, 8, 9 ; Kardanyamchi J10 ; Kazemian H2, 11
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  2. 2. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Biology, College of Natural Sciences, Jimma University, Ethiopia
  4. 4. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Health Information Management, School of School of Allied Medical Sciences, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  6. 6. Department of Information Science, Jimma Institute of Technology, Jimma University, Ethiopia
  7. 7. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  8. 8. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Public Health, College of Medical and Health Sciences, Ambo University, Ethiopia
  10. 10. Department of Pathobiology, Division of Microbiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  11. 11. Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran

Source: Heliyon Published:2019


Abstract

Introduction: Antitubercular drug resistance strain is a horrifying barrier to effective TB treatment and prevention. The present study aimed to determine the prevalence and geographical distribution of rifampicin-resistance M. tuberculosis (MTB) strains. Methods: We searched two electronic databases, PubMed and EMBASE, until 26 March 2017 and updated our search on 27 April 2018 and accessed all prevalence studies of MTB strain and their drug susceptibility patterns to rifampicin. The pooled prevalence estimate was determined using random effects model. Results: We identified 23 studies satisfying the inclusion criteria. The proportion of rifampicin resistance strains was diverged depending on the type of strains, country and Regions. The pooled estimate of rifampicin-resistance strains of MTB for the included studies was 4% (95% CI: 3–5%). In subgroup analysis based on World Health Organization (WHO) Regions, the pooled estimate of rifampicin-resistance strains of MTB was 11% (95% CI: 9–13%) with the Western Pacific Region 24%, Europian Region 10%, South-East Asian Region 6%, African Region 3% and Region of American 1%. Beijing family was the most dominant strain resistance to rifampicin with pooled prevalence of 14% (95% CI: 10–18%). The pooled prevalence of other families, i.e. EAI, T, CAS, MANU, Haarlem, LAM and Ural, was ≤2% for each. Conclusion: High burden of rifampicin resistance MTB strains was identified in the Western Pacific Region. Of these, Beijing family was predominantly resistance to rifampicin in Western Pacific Region and South-East Asian Region and also spread to European Region and Region of American. © 2018
Other Related Docs
9. High Genetic Diversity Among Mycobacterium Tuberculosis Strains in Tehran, Iran, Journal of Clinical Tuberculosis and Other Mycobacterial Diseases (2018)
18. In Vitro Anti-Mycobacterial Activity of Three Medicinal Plants of Lamiaceae Family, Recent Patents on Anti-Infective Drug Discovery (2018)