Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones

Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones Publisher

Mahdavi M¹ ; Asadi M² ; Khoshbakht M³ ; Saeedi M^{4, 5} ; Bayat M³ ; Foroumadi A² ; Shafiee A²

Show Affiliations

1. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran
3. Department of Chemistry, Imam Khomeini International University, Qazvin, 34184-96818, Iran
4. Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, 14176, Iran
5. Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, 14176, Iran

Source: Helvetica Chimica Acta Published:2016

Abstract

A series of novel quinazolin-4(3H)-one derivatives were efficiently synthesized starting from isatoic anhydride. First, reaction of isatoic anhydride and amines in H2O at room temperature afforded 2-aminobenzamides. Then, CuBr/Et3N promoted reaction of 2-aminobenzamides and different aryl isothiocyanates in DMF at 80° afforded the title compounds in good yield. © 2016 Verlag Helvetica Chimica Acta AG, Zurich.

Style	Citing Format
MLA	Mahdavi M, et al.. "Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones." Helvetica Chimica Acta, vol. 99, no. 5, 2016, pp. 378-383.
APA	Mahdavi M, Asadi M, Khoshbakht M, Saeedi M, Bayat M, Foroumadi A, Shafiee A (2016). Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones. Helvetica Chimica Acta, 99(5), 378-383.
Chicago	Mahdavi M, Asadi M, Khoshbakht M, Saeedi M, Bayat M, Foroumadi A, Shafiee A. "Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones." Helvetica Chimica Acta 99, no. 5 (2016): 378-383.
Harvard	Mahdavi M et al. (2016) 'Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones', Helvetica Chimica Acta, 99(5), pp. 378-383.
Vancouver	Mahdavi M, Asadi M, Khoshbakht M, Saeedi M, Bayat M, Foroumadi A, et al.. Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones. Helvetica Chimica Acta. 2016;99(5):378-383.
BibTex	@article{ author = {Mahdavi M and Asadi M and Khoshbakht M and Saeedi M and Bayat M and Foroumadi A and Shafiee A}, title = {Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones}, journal = {Helvetica Chimica Acta}, volume = {99}, number = {5}, pages = {378-383}, year = {2016} }
RIS	TY - JOUR AU - Mahdavi M AU - Asadi M AU - Khoshbakht M AU - Saeedi M AU - Bayat M AU - Foroumadi A AU - Shafiee A TI - Cubr/Et3n-Promoted Reactions of 2-Aminobenzamides and Isothiocyanates: Efficient Synthesis of Novel Quinazolin-4(3H)-Ones JO - Helvetica Chimica Acta VL - 99 IS - 5 SP - 378 EP - 383 PY - 2016 ER -

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