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Copper-Catalyzed Efficient Synthesis of 5-Arylindazolo[3,2-B]Quinazolin-7(5H)-Ones From 2-Nitrobenzaldehydes Publisher



Arasteh Fard Z1 ; Dilmaghani KA1 ; Soheilizad M2 ; Larijani B3 ; Mahdavi M3
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Faculty of Sciences, Urmia University, Urmia, Iran
  2. 2. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
  3. 3. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Tetrahedron Published:2018


Abstract

A novel and practical copper-catalyzed approach was developed for the preparation of 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones. The 2-amino-N′-arylbenzohydrazideis easily prepared by a reaction of isatoic anhydride with arylhydrazine. Then, through a condensation/intramolecular cyclization reaction by 2-nitrobenzaldehydes in the present of CuI, the corresponding 5-arylindazolo[3,2-b]quinazolin-7(5H)-ones are produced in good yields. © 2018