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A Critical Review on Akkermansia Muciniphila: Functional Mechanisms, Technological Challenges, and Safety Issues Publisher Pubmed



Abbasi A1 ; Bazzaz S2 ; Da Cruz AG3 ; Khorshidian N2 ; Saadat YR4 ; Sabahi S5 ; Ozma MA6 ; Lahouty M7 ; Aslani R8 ; Mortazavian AM2
Authors
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Authors Affiliations
  1. 1. Student Research Committee, Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Food Science and Technology, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Science and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Food Processing, Federal Institute of Science and Technology Education of Rio de Janeiro (IFRJ), Rio de Janeiro, Campus Maracana, Rio de Janeiro, Brazil
  4. 4. Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  5. 5. Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Medical Bacteriology and Virology, Tabriz University of Medical Sciences, Tabriz, Iran
  7. 7. Department of Microbiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  8. 8. Food Safety and Hygiene Division, Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Probiotics and Antimicrobial Proteins Published:2023


Abstract

Due to its physiological benefits from in vitro and in vivo points of view, Akkermansia muciniphila, a common colonizer in the human gut mucous layer, has consistently been identified as an option for the next-generation probiotic. A. muciniphila is a significant bacterium that promotes host physiology. However, it also has a great deal of potential to become a probiotic due to its physiological advantages in a variety of therapeutic circumstances. Therefore, it can be established that the abundance of A. muciniphila in the gut environment, which is controlled by many genetic and dietary variables, is related to the biological behaviors of the intestinal microbiota and gut dysbiosis/eubiosis circumstances. Before A. muciniphila is widely utilized as a next-generation probiotic, regulatory obstacles, the necessity for significant clinical trials, and the sustainability of manufacturing must be eliminated. In this review, the outcomes of recent experimental and clinical reports are comprehensively reviewed, and common colonization patterns, main factors involved in the colonization of A. muciniphila in the gut milieu, their functional mechanisms in establishing homeostasis in the metabolic and energy pathways, the promising delivery role of microencapsulation, potential genetic engineering strategies, and eventually safety issues of A. muciniphila have been discussed. © 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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