Inspection of Heritable Gut Microbiota Roles in Obesity Publisher



Hoseinitavassol Z¹ ; Ejtahed HS^{1, 2} ; Ettehadmarvasti F¹ ; Saghafian F¹ ; Ghannadi S^{1, 3} ; Khalagi K^{1, 4} ; Siadat SD⁵ ; Hasaniranjbar S¹ Show Affiliations
Source: Journal of Biological Regulators and Homeostatic Agents Published:2023

Abstract

Nowadays, obesity as a widespread disorder challenges health system worldwide. Obesity is a multifactorial disease. It may cause by various interactions between host genetic and environmental factors. Gut microbiota also have been recognized as a conclusive influential factor in obesity. While it is now widely accepted that the gut microbiota plays an important role in host metabolism, recent researches revealed that gut microbiota are also associated with genetic variations. Current knowledge about the influence of host genetics on specific gut microbiota is limited. But some of these heritable microbiota have a role in obesity incidence based on previous studies. So, it seems that an investigation about association of heritable gut microbiota with obesity is needed. In this study, we summarized recently known hereditary bacteria colonized in the gut and their effects on obesity. Here we discussed about, Akkermansia, Blautia, Christensenella and Faecalibacterium genera belong to Firmicutes, and Bifidobacterium genus is included in Bacteroidetes, as heritable taxa. This review can provide a perspective to advance studies on the developing of probiotics for obesity treatment and modifying individuals’ gut microbiota based on their genetics to resolve obesity problem and its prevention. © 2023 The Author(s).