Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Association of Normal Weight Obesity Phenotype With Inflammatory Markers: A Systematic Review and Meta-Analysis Publisher Pubmed



Mohammadian Khonsari N1 ; Baygi F2 ; Tabatabaeimalazy O3 ; Mohammadpoor Nami S1 ; Ehsani A4 ; Asadi S1 ; Qorbani M1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
  2. 2. Research Unit of General Practice, Department of Public Health, University of Southern Denmark, Odense, Denmark
  3. 3. Endocrinology and Metabolism Population Sciences Institute, Non-Communicable Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Pediatric, Iran University of Medical Sciences, Tehran, Iran

Source: Frontiers in Immunology Published:2023


Abstract

Background: Individuals with normal weight could suffer from obesity based on their body fat percentage (also known as normal weight obesity (NWO)), thus being at risk of significant morbidity and mortality compared to the general population. It seems that inflammatory pathways and chronic inflammation are significant contributors to the pathogenicity of NWO. This study aimed to assess and pool the association of proinflammatory and anti-inflammatory cytokines with NWO. Methods: In this systematic review and meta-analysis, online international databases (PubMed, Scopus, EMBASE, Web of Science, and Google Scholar) were searched until August 2022. All observational studies with an English full text comparing the mean levels of proinflammatory and anti-inflammatory cytokines (e.g., C-reactive protein (CRP), various types of interleukins (IL) s, tumor necrosis factor-alpha (TNF)) and white blood cell (WBC) count, in subjects with NWO and “normal weight non-obese (NWNO)” were included. Two researchers independently screened, reviewed and assessed the quality of included studies. The remaining articles’ data were extracted post-screening. The heterogeneity between studies was assessed using the I2 and Cochran’s Q tests. A random effect model meta-analysis was used to pool the standardized mean difference (SMD) as an effect size. Results: From the initial 559 studies, 21 and 19 were included in the qualitative and quantitative synthesis, respectively. In the systematic review, 8 studies reported a significant association between various proinflammatory cytokines (CRP, IL6, IL1β, and TNFα) and NWO. According to random-effect meta-analysis, the association between NWO with CRP (SMD: 0.60, 95% CI: 0.30, 0.91) and IL6 (SMD: 0.90, 95%CI: 0.14, 1.66) was statistically significant. Moreover, the mean level of TNFα in subjects with NWO and NWNO did not differ significantly (SMD: 0.67, 95% CI: -0.36, 1.70). Conclusion: The findings of this study show that NWO was associated with high levels of CRP and IL6. Therefore, inflammatory pathways may play a role in the pathogenicity of NWO. Copyright © 2023 Mohammadian Khonsari, Baygi, Tabatabaei-Malazy, Mohammadpoor Nami, Ehsani, Asadi and Qorbani.
Related Docs
View other Related Docs
1. Normal Weight Obesity and Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis, Frontiers in Endocrinology (2022)
2. Are Women With Normal-Weight Obesity at Higher Risk for Cardiometabolic Disorders?, Biomedicines (2023)
3. Dietary and Biochemical Characteristics Associated With Normal-Weight Obesity, International Journal for Vitamin and Nutrition Research (2019)
4. Association of Adipocytokines With Lipid and Glycemic Profiles in Women With Normal Weight Obesity, BMC Endocrine Disorders (2020)
5. Association of Serum Complement C3 With Metabolic Syndrome Components in Normal Weight Obese Women, Journal of Diabetes and Metabolic Disorders (2017)
6. Waist to Height Ratio As a Simple Tool for Predicting Mortality: A Systematic Review and Meta-Analysis, International Journal of Obesity (2023)
7. Association of Thyroid Hormones With Resting Energy Expenditure and Complement C3 in Normal Weight High Body Fat Women, Thyroid Research (2019)
8. Trends in Anthropometric Indexes, Blood Pressure, Smoking and Lipids Over a Decade in Diabetic and Non-Diabetic Populations: Tehran Lipid and Glucose Study, Iranian Journal of Epidemiology (2015)
Experts (# of related papers)
View all Related Experts
Mohammad Reza Mohajeri Tehrani (2)
Saeed Hosseini (2)
Other Related Docs
9. Association Between Sugar-Sweetened Beverages and Waist Circumference in Adult Populations: A Meta-Analysis of Prospective Cohort Studies, Clinical Nutrition ESPEN (2021)
10. Inflammatory Cytokines and Type 2 Diabetes, Koomesh (2020)
11. The Association Between Diet Quality Index-International and Inflammatory Markers in Iranian Overweight and Obese Women, Frontiers in Nutrition (2023)
12. The Effects of N-Acetylcysteine on Serum Level of Inflammatory Biomarkers in Adults. Findings From a Systematic Review and Meta-Analysis of Randomized Clinical Trials, Cytokine (2020)
13. Cytokine Release Syndrome: Inhibition of Pro-Inflammatory Cytokines As a Solution for Reducing Covid-19 Mortality, European Cytokine Network (2020)
14. Tocilizumab in Transplantation, European Journal of Clinical Pharmacology (2020)
15. Metabolic Phenotypes of Obese, Overweight, and Normal Weight Individuals and Risk of Chronic Kidney Disease: A Systematic Review and Meta-Analysis, Archives of Endocrinology and Metabolism (2019)
16. Can Coenzyme Q10 Supplementation Effectively Reduce Human Tumor Necrosis Factor-Α and Interleukin-6 Levels in Chronic Inflammatory Diseases? a Systematic Review and Meta-Analysis of Randomized Controlled Trials, Pharmacological Research (2019)
17. Neck Circumference Percentiles of Iranian Children and Adolescents: The Weight Disorders Survey of Caspian Iv Study, International Journal of Endocrinology and Metabolism (2017)